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License and Collaboration Agreements (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Research and development $ 4,664 $ 6,730 $ 9,345 $ 12,558
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Research and development     500  
Pfizer | License | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
One-time, sales based milestone payment 10,000   10,000  
Milestone payment, sales threshold 250,000   250,000  
Royalty expense $ 400 $ 0 $ 600 $ 0
Pfizer | License | Minimum | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Royalty rates     7.50%  
Pfizer | License | Maximum | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Royalty rates     15.00%