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Related Party Transactions - Additional Information (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Novartis        
Related Party Transaction [Line Items]        
Payments to related parties $ 0   $ 0  
Silverstein Foundation | Funding Agreement        
Related Party Transaction [Line Items]        
Fund received from related parties $ 0 $ 0 $ 500,000 $ 0