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We consent to the reference to our firm under the caption "Experts" in the Registration Statement (Form S-3) and related Prospectus of Denali Therapeutics Inc. for the registration of 29,290,754 shares of its common stock and to the incorporation by reference therein of our reports dated February 27, 2024, with respect to the consolidated financial statements of Denali Therapeutics Inc., and the effectiveness of internal control over financial reporting of Denali Therapeutics Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2023, filed with the Securities and Exchange Commission.