Commitments and Contingencies - Narrative (Details)		1 Months Ended	12 Months Ended
	May 02, 2018 USD ($) ft²	Jul. 31, 2022 USD ($) ft²	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Feb. 28, 2023 USD ($)	Oct. 31, 2018 ft²
Loss Contingencies [Line Items]
Operating lease costs			$ 12,200,000	$ 11,200,000	$ 11,100,000
Sublease income			3,900,000	3,800,000	3,600,000
Future undiscounted sublease receipts			3,972,000
Subsequent Event
Loss Contingencies [Line Items]
Future undiscounted sublease receipts						$ 1,100,000
DMSA
Loss Contingencies [Line Items]
Purchase order executed			35,900,000	35,800,000
Costs incurred			28,600,000	17,400,000	10,800,000
Payments for development and manufacturing services			23,900,000	14,900,000	$ 7,300,000
Non-Cancellable Purchase Commitments
Loss Contingencies [Line Items]
Purchase commitments			32,300,000	28,300,000
Other Commitments
Loss Contingencies [Line Items]
Purchase commitments			1,600,000	1,700,000
SLC Facility
Loss Contingencies [Line Items]
Purchase commitments			5,600,000
Excluding DMSA
Loss Contingencies [Line Items]
Purchase commitments			9,600,000	$ 11,500,000
Headquarters Lease
Loss Contingencies [Line Items]
Area under lease | ft²	148,020
Lease period	10 years
Lease renewal option term	10 years
Headquarters Lease | Landlord Funded Tenant Improvements
Loss Contingencies [Line Items]
Tenant improvement allowance repayable in rent	$ 4,400,000
Operating Lease, 8 Year Lease Agreement | Building | SLC Lease
Loss Contingencies [Line Items]
Lease not yet commenced, undiscounted lease payments		$ 19,500,000
Lease not yet commenced, lease liability			0
Lease not yet commenced, ROU asset			0
Lease not yet commenced, operating lease expense			$ 0
New Premises Sublease Agreement
Loss Contingencies [Line Items]
Rentable square feet | ft²							36,835
Sublease term							5 years
Operating Lease, 9.3 Year Lease Agreement | Building | SLC Lease
Loss Contingencies [Line Items]
Lease not yet commenced, area under lease | ft²		78,000
Lease not yet commenced, period		9 years 3 months 18 days
Minimum | Headquarters Lease
Loss Contingencies [Line Items]
Lease renewal notice period	9 months
Maximum | Headquarters Lease
Loss Contingencies [Line Items]
Lease renewal notice period	12 months
Maximum | Headquarters Lease | Landlord Funded Tenant Improvements
Loss Contingencies [Line Items]
Leasehold improvements	$ 25,900,000