ISSUER FREE WRITING PROSPECTUS
Dated January 26, 2018
Filed pursuant to Rule 433
Registration Statement No. 333-222546

BIOFRONTERA AG

FREE WRITING PROSPECTUS

Before deciding to invest in the American Depositary Shares of Biofrontera AG (the “Company”), you should read the preliminary prospectus, dated January 25, 2018, in its entirety. This free writing prospectus, attached as Annex A hereto, is qualified in its entirety by reference to the preliminary prospectus. The preliminary prospectus has preceded or accompanies this free writing prospectus and is available from the Securities and Exchange Commission’s website at https://www.sec.gov/Archives/edgar/data/1712641/000161577418000575/s108802_f1a.htm

The Company has filed a registration statement (including a prospectus) with the Securities and Exchange Commission for the offering to which this communication relates. Before you invest, you should read the prospectus in that registration statement for more complete information about the Company and this offering. You may get these documents for free by visiting EDGAR on the website of the Securities and Exchange Commission at www.sec.gov.

Annex A

Free Writing Prospectus