XML 41 R28.htm IDEA: XBRL DOCUMENT v3.22.1
License Agreements (Details) - USD ($)
12 Months Ended
Jun. 30, 2020
May 31, 2020
May 14, 2020
Feb. 01, 2020
May 18, 2018
Dec. 31, 2021
Dec. 31, 2020
License Agreements (Details) [Line Items]              
License initiation fee             $ 10,000
Option exercise fee             10,000
Patent related expense             15,000
Related with warrants granted           $ 100,000 134,000
Milestone payments     $ 3,500,000     6,000  
Annual license maintenance fee           2,500 2,500
Yearly minimum annual royalty fee           5,000 5,000
Patent expense Reimbursement             2,000
Upfront license payment             7,500
Milestone payments $ 1,375,000            
The George Washington University [Member]              
License Agreements (Details) [Line Items]              
Licensed product, description       the Company entered into a patent license agreement with GW pursuant to which GW granted the Company a license to certain patent rights to, among other things, make, use, offer and sell certain licensed products throughout the world with respect to HT-001. On the GW Effective Date, the Company paid GW $2,500, and on February 27, 2020, the Company paid GW $10,000 as a license initiation fee. Until the first commercial sale of HT-001, the Company shall pay (i) $75,000 per year for the development and commercialization of HT-001, (ii) $2,000 for license maintenance fees on the first anniversary of the GW Effective Date and (iii) $5,000 for license maintenance fees commencing on the second anniversary of the GW Effective Date and thereafter. Furthermore, the Company shall be required to pay GW a sublicense fee equal to a certain percentage of the sum of payments plus the fair market value of all other consideration of any kind received by the Company from sublicensees during each quarter as follows: a 40% sublicense fee until the first anniversary of the GW Effective Date, a 30% sublicense fee until the third anniversary of the GW Effective Date and a 20% sublicense fee after the third anniversary of the GW Effective Date; provided, however, such sublicense fee shall exclude certain fees paid to the Company such as certain royalties, equity investments, loan proceeds and sponsored research funding. The Company shall also pay GW milestone payments of up to an aggregate of $90,000 and sales-based royalties at a low single digit percentage, subject to certain minimum royalty requirements.      
University of Maryland and Isoprene Pharmaceuticals, Inc [Member]              
License Agreements (Details) [Line Items]              
License fee             10,000
Option exercise fee             20,000
Accrued license payment             5,000
Isoprene Pharmaceuticals, Inc. [Member]              
License Agreements (Details) [Line Items]              
License fee           15,000  
North Carolina State University [Member]              
License Agreements (Details) [Line Items]              
License fee           30,000  
Virginia Commonwealth University [Member]              
License Agreements (Details) [Line Items]              
Signing fee   $ 50,000          
Annual maintenance fees           30,000 30,000
Annual minimum payments           285,000  
University Of Cincinnati [Member]              
License Agreements (Details) [Line Items]              
Annual license maintenance fee           5,000 5,000
Yearly minimum annual royalty fee           $ 5,000 5,000
Upfront license payment             10,500
Milestone payments         $ 120,000    
Accrued license payment         5,000    
Annual royalty fee         $ 5,000    
U.S. Army Medical Research and Development Command [Member]              
License Agreements (Details) [Line Items]              
Accrued license payment             $ 2,000