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Summary of Significant Accounting Policies - Additional Information (Detail)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Jun. 30, 2021
USD ($)
ft²
Mar. 31, 2022
USD ($)
shares
Mar. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
Nov. 30, 2020
$ / shares
shares
Oct. 31, 2020
shares
Significant Accounting Policies [Line Items]              
Restricted cash deposit   $ 2,070   $ 2,070      
Restricted cash noncurrent   $ 2,070 $ 327 $ 2,070 $ 327    
Common stock, shares issued | shares   112,781,291   110,340,281      
Payment of exchange fees   $ 235 $ 85        
Common stock shares issued warrant to purchase | shares           30,000  
Common stock warrants exercise price per share | $ / shares           $ 3.29  
Agreement termination period   60 days          
Agreement written notice period   30 days          
Ultragenyx [Member] | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member]              
Significant Accounting Policies [Line Items]              
Common stock, shares issued | shares             7,825,797
Office laboratory [Member] | Hood Park LLC [Member]              
Significant Accounting Policies [Line Items]              
Area of lease agreement | ft² 49,869            
Lease description   The Company expects to relocate its corporate headquarters to the Premises in May 2022. The term of the lease commences on the later of (i) the date the Landlord delivers the Premises to the Company or (ii) the earlier of (a) the date the Company’s work on the Premises is substantially completed, (b) the date the Company commences business operations in the Premises, or (c) the one hundred twentieth (120th) day following the Landlord’s satisfaction of item (i) above. The lease commencement date is anticipated to be in the second quarter of 2022.          
Lease term 10 years            
Operating lease, monthly payments $ 305            
Operating lease payments annual escalation percentage 3.00%            
Construction allowance $ 10,223            
Lease renewal term 5 years            
Letter of credit amount   $ 1,833          
Tenant improvement allowance receivable   $ 6,171          
Operating lease, termination date   2022-06