Balance Sheet Components

12 Months Ended

Dec. 31, 2021

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

8.Balance Sheet Components

Property and Equipment, net

Property and equipment, net consists of the following:

	December 31,
	2021			2020
	(in thousands)
Laboratory equipment	$	20,012		$	16,769
Computer equipment		1,112			556
Furniture and fixtures		1,443			1,444
Leasehold improvements		7,834			7,274
Construction in progress		26,925			1,135
Property and equipment, gross		57,326			27,178
Less accumulated depreciation and amortization		(14,492	)		(9,232	)
Total property and equipment, net	$	42,834		$	17,946

Depreciation and amortization expenses were $5.3 million, $4.4 million and $3.3 million for the years ended December 31, 2021, 2020 and 2019, respectively.

Accrued and Other Liabilities

Accrued and other liabilities consist of the following:

	December 31,
	2021		2020
	(in thousands)
Milestone payable	$	95,000	$	—
Accrued royalties		58,672		—
Research and development expenses		28,073		49,384
Payroll and related expenses		29,753		17,060
Accrued income taxes		6,217		—
Excess funds payable under grant agreements		1,825		3,467
Operating lease liabilities, current		3,927		3,625
Other professional and consulting expenses		2,791		2,595
Other accrued expenses		10,254		805
Total accrued and other liabilities	$	236,512	$	76,936