Consolidated Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenues
Product revenue, net	$ 266,719,000	$ 212,672,000	$ 144,105,000
Collaboration revenue	0	2,368,000	207,000
Total revenues	266,719,000	215,040,000	144,312,000
Expenses
Cost of sales	(95,816,000)	(74,018,000)	(52,239,000)
Research and development	(265,868,000)	(286,408,000)	(573,306,000)
Selling, general and administrative	(281,608,000)	(258,971,000)	(218,831,000)
Gain on sale of intellectual property	10,000,000	0	0
Loss from operations	(366,573,000)	(404,357,000)	(700,064,000)
Interest income	39,797,000	14,582,000	2,190,000
Foreign currency (loss) gain	(14,850,000)	(56,403,000)	4,661,000
Other income (expense), net	7,006,000	3,113,000	(10,201,000)
Loss before income tax and share of loss from equity method investment	(334,620,000)	(443,065,000)	(703,414,000)
Income tax expense	0	0	0
Share of loss from equity method investment	0	(221,000)	(1,057,000)
Net loss	$ (334,620,000)	$ (443,286,000)	$ (704,471,000)
Loss per share — basic (in dollars per share)	$ (0.35)	$ (0.46)	$ (0.76)
Loss per share — diluted (in dollars per share)	$ (0.35)	$ (0.46)	$ (0.76)
Weighted-average shares used in calculating net loss per ordinary share — basic (in shares)	966,394,130	958,067,140	929,921,120
Weighted-average shares used in calculating net loss per ordinary share —diluted (in shares)	966,394,130	958,067,140	929,921,120