Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Total	Ordinary shares	Additional paid in capital	Accumulated deficit	Accumulated other comprehensive income (loss)	Treasury Stock
Beginning balance (in shares) at Dec. 31, 2019		682,372,470
Beginning balance at Dec. 31, 2019	$ 294,660	$ 4	$ 734,734	$ (444,698)	$ 4,620
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		2,257,680
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares option (in shares)		8,993,610
Exercise of shares option	6,664	$ 0	6,664
Issuance of ordinary shares upon follow-on public offering, net of issuance cost (in shares)		63,000,000
Issuance of ordinary shares upon follow-on public offering, net of issuance cost	280,549	$ 0	280,549
Issuance of ordinary shares upon secondary listing/ in connection with collaboration and license arrangement, net of issuance cost (in shares)		121,486,500
Issuance of ordinary shares upon secondary listing/ in connection with collaboration and license arrangement, net of issuance cost	850,691	$ 1	850,690
Share-based compensation	24,830		24,830
Net loss	(268,905)			(268,905)
Foreign currency translation	(19,144)				(19,144)
Ending balance (in shares) at Dec. 31, 2020		878,110,260
Ending balance at Dec. 31, 2020	1,169,345	$ 5	1,897,467	(713,603)	(14,524)	$ 0
Ending balance (in shares) at Dec. 31, 2020						0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		2,054,500
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares option (in shares)		12,353,400
Exercise of shares option	7,417	$ 0	7,417
Issuance of ordinary shares upon follow-on public offering, net of issuance cost (in shares)		57,164,000
Issuance of ordinary shares upon follow-on public offering, net of issuance cost	818,036	$ 1	818,035
Issuance of ordinary shares upon secondary listing/ in connection with collaboration and license arrangement, net of issuance cost (in shares)		5,681,820
Issuance of ordinary shares upon secondary listing/ in connection with collaboration and license arrangement, net of issuance cost	62,250	$ 0	62,250
Issuance cost adjustment for secondary listing	65		65
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation (in shares)						(382,930)
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation	(4,279)					$ (4,279)
Share-based compensation	40,714		40,714
Net loss	(704,471)			(704,471)
Foreign currency translation	$ (9,121)				(9,121)
Ending balance (in shares) at Dec. 31, 2021	954,981,050	955,363,980
Ending balance at Dec. 31, 2021	$ 1,379,956	$ 6	2,825,948	(1,418,074)	(23,645)	$ (4,279)
Ending balance (in shares) at Dec. 31, 2021	(382,930)					(382,930)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		1,940,680
Issuance of ordinary shares upon vesting of restricted shares	$ 0	$ 0	0
Exercise of shares option (in shares)	5,151,190	5,151,190
Exercise of shares option	$ 5,870	$ 0	5,870
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation (in shares)						(1,853,350)
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation	(7,577)					$ (7,577)
Share-based compensation	61,302		61,302
Net loss	(443,286)			(443,286)
Foreign currency translation	$ 49,330				49,330
Ending balance (in shares) at Dec. 31, 2022	960,219,570	962,455,850
Ending balance at Dec. 31, 2022	$ 1,045,595	$ 6	$ 2,893,120	$ (1,861,360)	$ 25,685	$ (11,856)
Ending balance (in shares) at Dec. 31, 2022	(2,236,280)					(2,236,280)