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STOCK-BASED COMPENSATION (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation The Company recorded stock-based compensation expense in the following award type categories included within the condensed consolidated statements of operations and comprehensive loss:
Three Months Ended
September 30,		Nine Months Ended
September 30,

2022202120222021
Stock options$2,481 $2,783 $8,674 $9,793 
Restricted stock units108 134 418 694 
Employee Stock Purchase Plan and Other75 92 199 174 

$2,664 $3,009 $9,291 $10,661 
The Company recorded stock-based compensation expense in the following expense categories of its condensed consolidated statements of operations and comprehensive loss:
Three Months Ended
September 30,		Nine Months Ended
September 30,

2022

202120222021
Research and development$1,201 

$732 $4,255 $4,586 
General and administrative1,463 

2,277 5,036 6,075 

$2,664 

$3,009 $9,291 $10,661 
Schedule of Stock Option Activity The following table summarizes the stock option activity under the Company’s equity awards plans:

Options

Weighted
Average
Exercise
Price

Weighted
Average
Remaining
Life
(in Years)

Intrinsic
Value
(in thousands)
Outstanding December 31, 20214,903,839 $17.38 7.6$847 
Granted1,882,450 $3.33 
Exercised(4,973)$3.20 
Cancelled or forfeited(1,042,595)$16.16 
Outstanding September 30, 20225,738,721 $13.00 7.8$27 
Options vested or expected to vest at September 30, 20225,738,721 $13.00 7.8$27 
Options exercisable at September 30, 20222,650,851 $15.78 6.6$27 
Schedule of Restricted Stock Activity The following table summarizes time-based restricted stock activity since January 1, 2022:

Number of
shares
Weighted
average
grant date
fair value
Unvested restricted common stock as of December 31, 202130,667 $29.53 
Granted185,795 $2.32 
Vested(15,560)$29.13 
Cancelled or forfeited(31,023)$4.28 
Unvested restricted common stock as of September 30, 2022169,879 $4.42