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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Cash flows from operating activities:    
Net loss $ (19,423) $ (23,258)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 159 189
Non-cash lease cost 199 110
Share-based compensation 2,009 1,110
Unrealized foreign currency transaction (gain) loss (19) 453
Accretion of discount on marketable securities 64 (53)
Changes in operating assets and liabilities:    
Other receivables (3,218) 5,036
Prepaid expenses and other current assets 869 (860)
Tax incentive receivables 772 (233)
Other assets   (1,224)
Accounts payable 2,689 4,824
Accrued expenses and other current liabilities 624 (9,287)
Other long-term liabilities (9) (44)
Operating lease liability (195) (92)
Net cash used in operating activities (15,479) (23,329)
Cash flows from investing activities:    
Purchases of marketable securities (2,997) (3,995)
Proceeds from maturities of marketable securities 6,000 31,850
Purchases of property and equipment   (79)
Net cash provided by (used in) investing activities 3,003 27,776
Cash flows from financing activities:    
Proceeds from equity offering 4,253  
Payment of offering and financing costs (37) (352)
Proceeds from stock option exercises 93 539
Net cash provided by financing activities 4,309 30,186
Net increase (decrease) in cash and cash equivalents (8,167) 34,633
Cash, cash equivalents and restricted cash at beginning of period 85,209 29,730
Cash, cash equivalents and restricted cash at end of period 77,042 64,363
Supplemental disclosure of non-cash activities:    
Offering and financing costs in accounts payable and accruals $ 93 109
Rights Offering [Member]    
Cash flows from financing activities:    
Proceeds from equity offering   9,416
Series C Preferred Stock [Member]    
Cash flows from financing activities:    
Payment of offering and financing costs   (41)
Supplemental disclosure of non-cash activities:    
Series C issuance costs in accounts payable   41
Series C Preferred Stock [Member] | Rights Offering [Member]    
Cash flows from financing activities:    
Proceeds from issuance of Series C Preferred Stock related to Rights Offering   $ 20,583