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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities:    
Net loss $ (59,695) $ (35,939)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 570 861
Non-cash lease cost 386  
Share-based compensation 3,523 2,847
Realized (gain) loss on investments   (1)
Unrealized foreign currency transaction (gain) loss (235) 164
Accretion of discount on marketable securities (57) (663)
Changes in operating assets and liabilities:    
Other receivables 686 (4,637)
Prepaid expenses and other current assets (2,474) 3,802
Tax incentive receivables (238) (319)
Other assets (1,890) (432)
Accounts payable (1,656) (1,041)
Accrued expenses and other current liabilities (8,346) 2,749
Other long-term liabilities (63) (44)
Net cash used in operating activities (69,489) (32,653)
Cash flows from investing activities:    
Purchases of marketable securities (3,995) (76,523)
Proceeds from maturities of marketable securities 54,350 110,337
Purchases of property and equipment (145) (185)
Net cash provided by (used in) investing activities 50,210 33,629
Cash flows from financing activities:    
Proceeds from equity offering 9,163 10,289
Payment of offering costs (580) (158)
Proceeds from stock option exercises 1,009 410
Net cash provided by financing activities 114,791 10,541
Net increase (decrease) in cash and cash equivalents 95,512 11,517
Cash, cash equivalents and restricted cash at beginning of period 29,730 34,080
Cash, cash equivalents and restricted cash at end of period 125,242 $ 45,597
Supplemental disclosure of non-cash activities:    
Offering costs in accounts payable and accruals 389  
Right of use assets and lease obligations recorded upon commencement of new lease 2,626  
Rights Offering [Member]    
Cash flows from financing activities:    
Proceeds from equity offering 9,416  
Underwritten Public Offering [Member]    
Cash flows from financing activities:    
Proceeds from equity offering 44,979  
Series C Preferred Stock [Member]    
Cash flows from financing activities:    
Payment of offering costs (41)  
Series C Preferred Stock [Member] | Rights Offering [Member]    
Cash flows from financing activities:    
Proceeds from issuance of Preferred Shares 20,583  
Series D Preferred Stock [Member]    
Cash flows from financing activities:    
Payment of offering costs (186)  
Series D Preferred Stock [Member] | Underwritten Public Offering [Member]    
Cash flows from financing activities:    
Proceeds from issuance of Preferred Shares $ 30,221