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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Cash flows from operating activities:    
Net loss $ (35,939) $ (31,063)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 861 270
Loss on disposal of fixed assets   248
Share-based compensation 2,847 1,980
Realized (gain) loss on investments (1)  
Unrealized foreign currency transaction (gain) loss 164 237
Accretion of discount on marketable securities (663) (346)
Changes in operating assets and liabilities:    
Other receivables (4,637) 679
Prepaid expenses and other current assets 3,802 706
Tax incentive receivables (319) 980
Other assets (432)  
Accounts payable (1,041) (2,088)
Accrued expenses and other current liabilities 2,749 2,372
Deferred rent   (91)
Other long-term liabilities (44)  
Net cash used in operating activities (32,653) (26,116)
Cash flows from investing activities:    
Purchases of marketable securities (76,523) (104,421)
Proceeds from maturities of marketable securities 110,337 14,000
Purchases of property and equipment (185) (22)
Net cash provided by (used in) investing activities 33,629 (90,443)
Cash flows from financing activities:    
Proceeds from the issuance of common stock, net of commissions 10,289 70,500
Payment of offering costs (158) (996)
Proceeds from stock option exercises 410 197
Net cash provided by financing activities 10,541 69,701
Net increase (decrease) in cash and cash equivalents 11,517 (46,858)
Cash, cash equivalents and restricted cash at beginning of period 34,080 87,338
Cash, cash equivalents and restricted cash at end of period $ 45,597 40,480
Supplemental disclosure of non-cash investing and financing activities:    
Offering costs included in accounts payable and accrued expenses   $ 246