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Non-Controlling Interests - Spero Gyrase - Additional Information (Detail) - USD ($)	1 Months Ended	3 Months Ended			6 Months Ended
	Mar. 31, 2016	Jun. 30, 2019	Mar. 31, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Noncontrolling Interest [Line Items]
Non-controlling interests		$ 355,000			$ 355,000		$ 355,000
Common stock issued, aggregate fair value		8,252,000	$ 1,525,000
Research and development expense		12,026,000		$ 7,374,000	21,552,000	$ 16,299,000
Proceeds from the issuance of common stock, net of issuance costs					10,251,000
Spero Gyrase, Inc. [Member]
Noncontrolling Interest [Line Items]
Non-controlling interests		$ 400,000			$ 400,000		$ 400,000
Spero Gyrase, Inc. [Member] \| Anti- dilution Rights [Member] \| Research and Development Expenses [Member]
Noncontrolling Interest [Line Items]
Fair value of derivative liability	$ 1,600,000
Spero Gyrase, Inc. [Member] \| Aviragen Therapeutics, Inc. [Member]
Noncontrolling Interest [Line Items]
Common stock shares issued	200
Common stock issued, aggregate fair value	$ 1,100,000
Ownership percentage	20.00%
Spero Gyrase, Inc. [Member] \| Aviragen Therapeutics, Inc. [Member] \| Anti- dilution Rights [Member]
Noncontrolling Interest [Line Items]
Ownership percentage	20.00%
Proceeds from the issuance of common stock, net of issuance costs	$ 0
Spero Gyrase, Inc. [Member] \| Aviragen Therapeutics, Inc. [Member] \| Anti- dilution Rights [Member] \| Maximum [Member]
Noncontrolling Interest [Line Items]
Gross proceeds from equity financings	8,000,000
Spero Gyrase, Inc. [Member] \| Aviragen Therapeutics, Inc. [Member] \| Technology-Based Intangible Assets [Member]
Noncontrolling Interest [Line Items]
Research and development expense	$ 1,100,000