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Leases - Additional Information (Detail)
1 Months Ended 3 Months Ended
Jan. 01, 2019
USD ($)
Jan. 17, 2018
USD ($)
ft²
Option
Jul. 31, 2016
USD ($)
Aug. 31, 2015
USD ($)
Mar. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Lessee Lease Description [Line Items]            
Annual lease payments         $ 316,000  
Meiji License Agreement [Member]            
Lessee Lease Description [Line Items]            
Embedded finance leases fixed assets related payments           $ 1,600,000
Finance lease liability         $ 0  
Office Space [Member]            
Lessee Lease Description [Line Items]            
Operating lease beginning date       2016-01    
Operating lease expiration date       2020-12    
Annual lease payments       $ 400,000    
Term of lease       5 years    
Operating lease, existence of option to extend       true    
Lease renewal term       5 years    
Security deposit       $ 200,000    
Annual rent escalations and tenant incentives       700,000    
Amount reimbursed       $ 300,000    
Operating lease decrease in right of use assets $ 200,000          
Office Space [Member] | Lease Agreements [Member] | Cambridge, Massachusetts [Member] | U.S. REIF Central Plaza Massachusetts, LLC [Memebr]            
Lessee Lease Description [Line Items]            
Term of lease   7 years        
Operating lease, existence of option to extend   true        
Lease renewal term   5 years        
Operating lease decrease in right of use assets $ 400,000          
Lease expiration date   Dec. 22, 2018        
Area of office space | ft²   7,800        
Number of renewal options | Option   2        
Operating lease, option to extend         the Company has two consecutive options to extend the Lease Term for an additional period of five years (the “Option Terms”), subject to certain conditions, upon notice to the Landlord.  
Operating leases annual base rent initial   $ 500,000        
Operating leases annual base rent final   $ 600,000        
Operating lease percentage of annual base rent   100.00%        
Leasehold improvements receivable from the Landlord   $ 400,000        
Laboratory Space [Member]            
Lessee Lease Description [Line Items]            
Annual lease payments     $ 300,000      
Lease expiration date         Nov. 30, 2019