Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Nature Of Business And Basis Of Presentation [Line Items]
Entity incorporation month and year	2013-12
State of incorporation	DE
Net income (loss)	$ 22,806	$ (46,415)
Accumulated deficit	$ 391,072	$ 413,878
Spero Therapeutics LLC [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Merger date	Jun. 30, 2017