Restructuring - Restructuring charges (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	$ 8,552
Other	3,078
Restructuring	11,630	$ 0
Research and Development Expense [Member]
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	3,872
Other	488
Restructuring	4,360
General and Administrative Expense [Member]
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	4,680
Other	2,590
Restructuring	$ 7,270