Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Domestic and Foreign Components of Loss before Income Taxes

The domestic and foreign components of loss before income taxes were as follows (in thousands):

	Year Ended December 31,
	2022			2021
Domestic	$	(46,249	)	$	(89,565	)
Foreign		(166	)		(191	)
Loss before income taxes	$	(46,415	)	$	(89,756	)

Reconciliation of U.S. Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate

A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows:

	Year Ended December 31,
	2022			2021
Federal statutory income tax rate		(21.0	)		(21.0	)
Federal and state research and development tax credit		(4.3	)		(3.1	)
State taxes, net of federal benefit		(2.3	)		(7.0	)
Nondeductible items		1.0			0.6
Increase in deferred tax asset valuation allowance		26.6			30.5
Effective income tax rate		—			—

Net Deferred Tax Assets

Net deferred tax assets as of December 31, 2022 and 2021 consisted of the following (in thousands):

	December 31,
	2022			2021
Net operating loss carryforwards	$	78,619		$	83,849
Research and development tax credit carryforwards		14,294			12,375
Capitalized research and development expenses, net		11,613			—
Other		10,264			6,220
Total deferred tax assets		114,790			102,444
Valuation allowance		(114,790	)		(102,444	)
Net deferred tax assets	$	—		$	—

Summary of Changes in Valuation Allowance for Deferred Tax Assets

Changes in the valuation allowance for deferred tax assets during the years ended December 31, 2022 and 2021 related primarily to the increase in net operating loss carryforwards and research and development tax credit carryforwards, and were as follows (in thousands):

	December 31,
	2022			2021
Valuation allowance as of beginning of year	$	(102,444	)	$	(75,039	)
Increases recorded to income tax provision		(12,346	)		(27,405	)
Valuation allowance as of end of year	$	(114,790	)	$	(102,444	)