Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Domestic and Foreign Components of Loss before Income Taxes

The domestic and foreign components of loss before income taxes were as follows (in thousands):

	Year Ended December 31,
	2021			2020
Domestic	$	(89,565	)	$	(77,671	)
Foreign		(191	)		(609	)
Loss before income taxes	$	(89,756	)	$	(78,280	)

Reconciliation of U.S. Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate

A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows:

	Year Ended December 31,
	2021			2020
Federal statutory income tax rate		(21.0	)		(21.0	)
Federal and state research and development tax credit		(3.1	)		(3.2	)
State taxes, net of federal benefit		(7.0	)		(6.2	)
Foreign rate differential		-			-
Nondeductible items		0.6			0.9
Increase in deferred tax asset valuation allowance		30.5			29.5
Effective income tax rate		—			—

Net Deferred Tax Assets

Net deferred tax assets as of December 31, 2021 and 2020 consisted of the following (in thousands):

	December 31,
	2021			2020
Net operating loss carryforwards	$	83,849		$	63,612
Research and development tax credit carryforwards		12,375			8,024
Other		6,220			3,403
Total deferred tax assets		102,444			75,039
Valuation allowance		(102,444	)		(75,039	)
Net deferred tax assets	$	—		$	—

Summary of Changes in Valuation Allowance for Deferred Tax Assets

Changes in the valuation allowance for deferred tax assets during the years ended December 31, 2021 and 2020 related primarily to the increase in net operating loss carryforwards and research and development tax credit carryforwards, and were as follows (in thousands):

	December 31,
	2021			2020
Valuation allowance as of beginning of year	$	(75,039	)	$	(51,980	)
Decreases recorded as benefit to income tax provision		—			—
Increases recorded to income tax provision		(27,405	)		(23,059	)
Valuation allowance as of end of year	$	(102,444	)	$	(75,039	)