0000899243-22-004589.txt : 20220203 0000899243-22-004589.hdr.sgml : 20220203 20220203161804 ACCESSION NUMBER: 0000899243-22-004589 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20220201 FILED AS OF DATE: 20220203 DATE AS OF CHANGE: 20220203 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Keutzer Timothy CENTRAL INDEX KEY: 0001798155 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 001-38266 FILM NUMBER: 22588537 MAIL ADDRESS: STREET 1: C/O SPERO THERAPEUTICS, INC. STREET 2: 675 MASSACHUSETTS AVENUE, 14TH FLOOR CITY: CAMBRIDGE STATE: MA ZIP: 02139 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: Spero Therapeutics, Inc. CENTRAL INDEX KEY: 0001701108 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 675 MASSACHUSETTS AVENUE STREET 2: 14TH FLOOR CITY: CAMBRIDGE STATE: MA ZIP: 02139 BUSINESS PHONE: 857-242-1600 MAIL ADDRESS: STREET 1: 675 MASSACHUSETTS AVENUE STREET 2: 14TH FLOOR CITY: CAMBRIDGE STATE: MA ZIP: 02139 FORMER COMPANY: FORMER CONFORMED NAME: Spero Therapeutics, LLC DATE OF NAME CHANGE: 20170316 4 1 doc4.xml FORM 4 SUBMISSION X0306 4 2022-02-01 0 0001701108 Spero Therapeutics, Inc. SPRO 0001798155 Keutzer Timothy C/O SPERO THERAPEUTICS, INC. 675 MASSACHUSETTS AVENUE, 14TH FLOOR CAMBRIDGE MA 02139 0 1 0 0 Chief Development Officer Common Stock 2022-02-01 4 A 0 38014 0.00 A 64581 D Stock Option (Right to Buy) 11.18 2022-02-01 4 A 0 53190 0.00 A 2032-02-01 Common Stock 53190 53190 D Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date. Includes 2,500 shares of common stock and 62,081 RSUs held by the Reporting Person. The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date. Exhibit 24.1 - Power of Attorney /s/ Tamara Joseph, Attorney-in-Fact for Timothy Keutzer 2022-02-03 EX-24.1 2 attachment1.htm EX-24.1 DOCUMENT

                           POWER OF ATTORNEY

        Know all by these present, that the undersigned hereby constitutes and
appoints each of Ankit Mahadevia, M.D., Satyavrat Shukla, Tamara Joseph, and
Meghan Small of Spero Therapeutics, Inc. (the "Company"), and Mathew J.
Gardella and Matthew W. Tikonoff of Mintz, Levin, Cohn, Ferris, Glovsky and
Popeo, P.C., signing singly, with full power of substitution, the undersigned's
true and lawful attorney-in-fact to:

        (1)   execute for and on behalf of the undersigned, forms and
              authentication documents for EDGAR Filing Access;

        (2)   do and perform any and all acts for and on behalf of the
              undersigned which may be necessary or desirable to complete and
              execute any such forms and authentication documents;

        (3)   execute for and on behalf of the undersigned, in the
              undersigned's capacity as an officer, director and/or 10%
              shareholder of the Company, Forms 3, 4, and 5 in accordance with
              Section 16(a) of the Securities and Exchange Act of 1934 and the
              rules thereunder;

        (4)   do and perform any and all acts for and on behalf of the
              undersigned which may be necessary or desirable to complete and
              execute any such Form 3, 4, or 5 and timely file such form with
              the United States Securities and Exchange Commission and any
              stock exchange or similar authority; and

        (5)   take any other action of any type whatsoever in connection with
              the foregoing which, in the option of such attorney-in-fact, may
              be of benefit to, in the best interests of, or legally required
              by the undersigned, it being understood that the documents
              executed by such attorney-in-fact on behalf of the undersigned
              pursuant to this Power of Attorney shall be in such form and
              shall contain such terms and conditions as such attorney-in-fact
              may approve in such attorney-in-fact's discretion.

        The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall
lawfully do or cause to be done by virtue of this power of attorney and the
rights and powers herein granted. The undersigned acknowledges that the
foregoing attorneys-in-fact, in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company assuming, any of the
undersigned's responsibilities to comply with Section 16 of the Securities
Exchange Act of 1934, as amended.

        This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holding of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

        IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed on this 10th day of September, 2021.

                                   /s/ Timothy Keutzer
                                   -------------------------------
                                   Timothy Keutzer