STOCK OPTIONS (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

SCHEDULE OF STOCK BASED COMPENSATION EXPENSES

Total stock-based compensation expense recognized for both employees and non-employees was as follows:

	Years Ended December 31,
	2022		2021		2020
General and administrative	$	11,183	$	7,462	$	7,611
Research and development		7,845		4,377		5,612
Total stock-based compensation expense	$	19,028	$	11,839	$	13,223

SUMMARY OF STOCK OPTION ACTIVITY

A summary of option activity for the years ended December 31, 2022 and 2021 are presented below:

						Weighted-
				Weighted-		Average
				Average		Remaining
	Underlying			Exercise		Contractual		Intrinsic
Stock Option Awards	Shares			Price		Term		Value
Outstanding at December 31, 2020		9,503		$	9.10		8.3 years
Granted		4,104		$	7.37
Exercised		(19	)	$	2.50
Forfeited or expired		(1,115	)	$	9.76
Outstanding at December 31, 2021		12,473		$	8.48		8.0 years
Granted		3,706		$	4.83
Exercised		(566	)	$	2.75
Forfeited or expired		(775	)	$	8.83
Outstanding at December 31, 2022		14,838		$	7.77		7.3 years	$	53,687
Exercisable at December 31, 2022		7,617		$	8.39		6.2 years	$	24,804

SCHEDULE OF AGGREGATED INTRINSIC VALUE OF STOCK OPTION EXERCISED

Cash proceeds from, and the aggregate intrinsic value of, stock options exercised during the periods presented below were as follows:

	Years Ended December 31,
	2022		2021		2020
Cash proceeds from options exercised	$	1,036	$	48	$	1,152
Aggregate intrinsic value of options exercised	$	3,420	$	239	$	1,615

SCHEDULE OF SHARE-BASED COMPENSATION VALUATION OF ASSUMPTIONS

The Company uses the Black-Scholes option-pricing model to estimate the fair value of option awards with the following weighted-average assumptions for the period indicated:

	Years Ended December 31,
	2022			2021			2020
Exercise price	$	4.83		$	7.37		$	12.87
Expected volatility		80	%		81	%		74	%
Expected dividends		—			—			—
Expected term (in years)		6.1			6.1			6.2
Risk-free interest rate		2.16	%		1.13	%		0.59	%