Leases - Additional Information (Detail) $ in Thousands	3 Months Ended		6 Months Ended
	Mar. 31, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($) ft²	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)
Leases [Line Items]
Restricted Cash, Noncurrent			$ 0		$ 1,780
Property sublease, description	The Company had a sublease, as amended, for up to approximately 69,000 square feet of office and laboratory space in Cambridge, Massachusetts. The sublease was subject and subordinate to a prime lease between the sublandlord and the prime landlord. The term of the sublease commenced in June 2018 and was set to expire in February 2028
Decrease in operating lease liability			(15,639)	$ (1,432)
Gain Loss On Termination Of Lease	$ (8,100)		$ (8,059)	0
Sub Sublease [Member]
Leases [Line Items]
Square feet of property subject to sublease | ft²			26,114
Other income from sub-sublease		$ 600	$ 900	$ 1,400
Office and Lab Sublease [Member]
Leases [Line Items]
Operating lease termination payment	$ 14,800
Office and Lab Sublease [Member] | Letter of Credit [Member]
Leases [Line Items]
Restricted Cash, Noncurrent					$ 1,800