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Leases - Additional Information (Detail)
$ in Thousands
3 Months Ended
Mar. 31, 2023
USD ($)
ft²
Mar. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
Leases [Line Items]      
Restricted Cash, Noncurrent $ 0   $ 1,780
Restricted Cash, Current $ 1,780   0
Property sublease, description The Company had a sublease, as amended, for up to approximately 69,000 square feet of office and laboratory space in Cambridge, Massachusetts. The sublease was subject and subordinate to a prime lease between the sublandlord and the prime landlord. The term of the sublease commenced in June 2018 and was set to expire in February 2028    
Decrease in operating lease liability $ (15,639) $ (692)  
Gain Loss On Termination Of Lease $ (8,059) 0  
Sub Sublease [Member]      
Leases [Line Items]      
Square feet of property subject to sublease | ft² 26,114    
Other income from sub-sublease $ 800 $ 800  
Office and Lab Sublease [Member]      
Leases [Line Items]      
Operating lease termination payment 14,800    
Office and Lab Sublease [Member] | Letter of Credit [Member]      
Leases [Line Items]      
Restricted Cash, Noncurrent     $ 1,800
Restricted Cash, Current $ 1,800