The amount of accrued expenses - related parties.

No definition available.

Name:	atnf_AccruedExpensesRelatedParties
Namespace Prefix:	atnf_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Amount of interest expense on loans.

+ References

No definition available.

+ Details

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Namespace Prefix:	atnf_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Loans payable - related parties.

+ References

No definition available.

+ Details

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Namespace Prefix:	atnf_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- References

No definition available.

+ Details

Name:	atnf_RelatedPartiesDetailsLineItems
Namespace Prefix:	atnf_
Data Type:	xbrli:stringItemType
Balance Type:	na
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- Definition

Amount of related party interest expense associated with convertible notes.

+ References

No definition available.

+ Details

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Namespace Prefix:	atnf_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
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- Definition

Research and development expenses - related parties.

+ References

No definition available.

+ Details

Name:	atnf_ResearchAndDevelopmentExpensesRelatedParties
Namespace Prefix:	atnf_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Stockholders percentage.

+ References

No definition available.

+ Details

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Namespace Prefix:	atnf_
Data Type:	dtr:percentItemType
Balance Type:	na
Period Type:	duration

- Definition

Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-03.15(a))
-URI https://asc.fasb.org/extlink&oid=126734703&loc=d3e572229-122910

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-03.15(5))
-URI https://asc.fasb.org/extlink&oid=126897435&loc=d3e534808-122878

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Amount of interest expense incurred on a debt or other obligation to related party.

+ References

No definition available.

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

The net amount of operating interest income (expense).

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04.10)
-URI https://asc.fasb.org/extlink&oid=120399700&loc=SL114874048-224260

+ Details

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

Amount of interest payable on debt, including, but not limited to, trade payables.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-03.15(5))
-URI https://asc.fasb.org/extlink&oid=126897435&loc=d3e534808-122878

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-03.15(a))
-URI https://asc.fasb.org/extlink&oid=126734703&loc=d3e572229-122910

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Amount of general and administrative expense classified as other.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.4)
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Details

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Namespace Prefix:
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Balance Type:
Period Type:

- Details

Name:	srt_TitleOfIndividualAxis=srt_DirectorMember
Namespace Prefix:
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Balance Type:
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- Details

Name:	srt_TitleOfIndividualAxis=srt_OfficerMember
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Balance Type:
Period Type:

- Details

Name:	srt_TitleOfIndividualAxis=us-gaap_OtherAffiliatesMember
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Data Type:	na
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- Details

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Related Parties (Details) - USD ($)	3 Months Ended		9 Months Ended
Related Parties (Details) - USD ($)	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Related Parties (Details) [Line Items]
Accrued expenses - related parties	$ 158,467		$ 158,467		$ 18,370
Interest accrued on loan	16,676		16,676
Accrued consulting fees	141,791		141,791
Loans payable - related parties	84,756		84,756		$ 81,277
Research and development expenses - related parties	53,347	$ 298,879	158,401	$ 1,287,583
General and administrative expenses - related parties	0	82,519	5,261	462,081
Interest (expense) income – related parties	$ (1,536)		1,495
Interest expense - related parties		14,201		42,279
Related party interest expense		3,633		$ 11,380
interest expense on loans		$ 10,567	$ 30,899
Related Parties [Member]
Related Parties (Details) [Line Items]
Stockholders percentage			5.00%
Directors [Member]
Related Parties (Details) [Line Items]
Stockholders percentage			5.00%
Officers [Member]
Related Parties (Details) [Line Items]
Stockholders percentage			5.00%
Affiliates [Member]
Related Parties (Details) [Line Items]
Stockholders percentage			5.00%
Officers and Director [Member]
Related Parties (Details) [Line Items]
Stockholders percentage			5.00%