CONDENSED CONSOLIDATED STATEMENTS STOCKHOLDERS’ EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid‑in Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit
Beginning balances (in shares) at Dec. 31, 2021		31,224,336
Beginning balances at Dec. 31, 2021	$ 298,718	$ 3	$ 392,384	$ 0	$ (93,669)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		24,891
Issuance of common stock upon exercise of stock options	50		50
Vesting of early exercised options (in shares)		15,224
Vesting of early exercised options	35		35
Stock-based compensation	1,794		1,794
Other comprehensive income (loss)	(1,535)			(1,535)
Net loss	(21,671)				(21,671)
Ending balances (in shares) at Mar. 31, 2022		31,264,451
Ending balances at Mar. 31, 2022	277,391	$ 3	394,263	(1,535)	(115,340)
Beginning balances (in shares) at Dec. 31, 2021		31,224,336
Beginning balances at Dec. 31, 2021	298,718	$ 3	392,384	0	(93,669)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Other comprehensive income (loss)	(2,747)
Net loss	(69,987)
Ending balances (in shares) at Sep. 30, 2022		31,325,373
Ending balances at Sep. 30, 2022	233,220	$ 3	399,620	(2,747)	(163,656)
Beginning balances (in shares) at Dec. 31, 2021		31,224,336
Beginning balances at Dec. 31, 2021	$ 298,718	$ 3	392,384	0	(93,669)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercised options (in shares)	53,741
Ending balances (in shares) at Dec. 31, 2022	31,394,767	31,394,767
Ending balances at Dec. 31, 2022	$ 212,554	$ 3	402,893	(2,057)	(188,285)
Beginning balances (in shares) at Mar. 31, 2022		31,264,451
Beginning balances at Mar. 31, 2022	277,391	$ 3	394,263	(1,535)	(115,340)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		5,259
Issuance of common stock upon exercise of stock options	11		11
Vesting of early exercised options (in shares)		14,738
Vesting of early exercised options	34		34
Stock-based compensation	2,512		2,512
Other comprehensive income (loss)	(730)			(730)
Net loss	(23,179)				(23,179)
Ending balances (in shares) at Jun. 30, 2022		31,284,448
Ending balances at Jun. 30, 2022	256,039	$ 3	396,820	(2,265)	(138,519)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		26,868
Issuance of common stock upon exercise of stock options	60		60
Vesting of early exercised options (in shares)		14,057
Vesting of early exercised options	33		33
Stock-based compensation	2,707		2,707
Other comprehensive income (loss)	(482)			(482)
Net loss	(25,137)				(25,137)
Ending balances (in shares) at Sep. 30, 2022		31,325,373
Ending balances at Sep. 30, 2022	$ 233,220	$ 3	399,620	(2,747)	(163,656)
Beginning balances (in shares) at Dec. 31, 2022	31,394,767	31,394,767
Beginning balances at Dec. 31, 2022	$ 212,554	$ 3	402,893	(2,057)	(188,285)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		18,344
Issuance of common stock upon exercise of stock options	129		129
Vesting of early exercised options (in shares)		10,153
Vesting of early exercised options	26		26
Vesting of restricted stock units (in shares)		91,859
Issuance of common stock in connection with the Vertex Agreement (in shares)		1,618,613
Issuance of common stock in connection with the Vertex Agreement	19,407		19,407
Stock-based compensation	2,755		2,755
Other comprehensive income (loss)	1,415			1,415
Net loss	(6,674)				(6,674)
Ending balances (in shares) at Mar. 31, 2023		33,133,736
Ending balances at Mar. 31, 2023	$ 229,612	$ 3	425,210	(642)	(194,959)
Beginning balances (in shares) at Dec. 31, 2022	31,394,767	31,394,767
Beginning balances at Dec. 31, 2022	$ 212,554	$ 3	402,893	(2,057)	(188,285)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)	145,149
Vesting of early exercised options (in shares)	21,149
Other comprehensive income (loss)	$ 1,561
Net loss	$ 2,859
Ending balances (in shares) at Sep. 30, 2023	33,340,216	33,340,216
Ending balances at Sep. 30, 2023	$ 246,663	$ 3	432,582	(496)	(185,426)
Beginning balances (in shares) at Mar. 31, 2023		33,133,736
Beginning balances at Mar. 31, 2023	229,612	$ 3	425,210	(642)	(194,959)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		46,175
Issuance of common stock upon exercise of stock options	257		257
Vesting of early exercised options (in shares)		9,468
Vesting of early exercised options	$ 25		25
Purchase of common stock under the employee stock purchase plan (in shares)	16,314
Purchase of common stock under the employee stock purchase plan	$ 186
Stock-based compensation	3,119		3,119
Other comprehensive income (loss)	(363)			(363)
Net loss	(25,928)				(25,928)
Ending balances (in shares) at Jun. 30, 2023		33,205,693
Ending balances at Jun. 30, 2023	206,908	$ 3	428,797	(1,005)	(220,887)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		80,630
Issuance of common stock upon exercise of stock options	368		368
Vesting of early exercised options (in shares)		7,391
Vesting of early exercised options	21		21
Vesting of restricted stock units (in shares)		46,502
Stock-based compensation	3,396		3,396
Other comprehensive income (loss)	509			509
Net loss	$ 35,461				35,461
Ending balances (in shares) at Sep. 30, 2023	33,340,216	33,340,216
Ending balances at Sep. 30, 2023	$ 246,663	$ 3	$ 432,582	$ (496)	$ (185,426)