Amount, after accumulated amortization, of debt discount.

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Value of input used to measure derivative liability.

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Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.

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The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt.

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Fair Value Measurements - Narrative (Details) $ in Millions	12 Months Ended
Fair Value Measurements - Narrative (Details) $ in Millions	Dec. 31, 2019 USD ($)	Dec. 31, 2017 USD ($)	Mar. 31, 2022	Dec. 31, 2021	Aug. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Aug. 31, 2017 USD ($)
Measurement Input, Probability of Change in Control
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Change in control			0.50	0.50
Line of Credit \| Madryn Credit Agreement
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of options							$ 15.1
Debt discount					$ 1.6	$ 5.0	$ 5.0
Additional amount borrowed	$ 25.0	$ 10.0