Exhibit 99.3

ObsEva Announces Third Quarter 2021 Financial Results

and Business Update

-Linzagolix for uterine fibroids: Pending regulatory approval in the US and Europe with commercial planning efforts underway-

-Linzagolix for endometriosis: Readout from Phase 3 EDELWEISS 3 study

expected in Q4:21-

-Ebopiprant: Global License Agreement completed with Organon -

-Actively pursuing new indications and partnerships to maximize value of pipeline candidates-

Ad hoc announcement pursuant to Art. 53 LR of the SIX Swiss Exchange

GENEVA, Switzerland – November 4, 2021 – ObsEva SA (NASDAQ: OBSV) (SIX: OBSN), a biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health, today reported financial results for the quarter ended September 30, 2021 and provided a business update.

“Recent months have been noteworthy for many reasons, especially the progress made in defining the futures of both the linzagolix and ebopiprant programs,” reported Brian O’Callaghan, CEO of ObsEva. “Regulatory filings for approval of linzagolix in the treatment of uterine fibroids have now been made in both Europe and the US. As a result, commercialization planning is now underway, via our recently announced relationship with Syneos Health to commercialize linzagolix.The future path of ebopiprant was also established with our license agreement with Organon to develop and commercialize ebopiprant. We are looking forward to seeing the advancement of this investigational agent to potentially benefit many patients in the future. As I reflect on my first year with the company, I am incredibly proud of our numerous achievements across all areas of the business, and I am increasingly confident in the team’s ability to continue to grow and redefine ObsEva’s future.”

Anticipated Milestones

ObsEva expects to achieve the following key clinical and regulatory objectives in 2021:

• Linzagolix for uterine fibroids: Committee for Medicinal Products for Human Use (CHMP) marketing approval recommendation (Q4:21)

• Linzagolix for endometriosis: Phase 3 EDELWEISS 3 study topline results readout (Q4:21)

Pipeline Update

• Linzagolix for Uterine Fibroids:  ObsEva is developing linzagolix, an oral GnRH receptor antagonist with the prospect to treat more women due to its potential best-in-class efficacy, a favorable tolerability profile and unique, and flexible dosing options for the treatment of uterine fibroids. If approved, linzagolix will be the only GnRH antagonist in uterine fibroids with a low dose non-ABT option to address the needs of women who cannot or do not want to take hormones. The Company is working closely with the European Medicines Agency (EMA) to achieve marketing approval, with an approval recommendation (positive opinion) from the CHMP projected in Q4:2021. In Q3:2021, the Company also submitted a New Drug Application with the US FDA. Commercial planning efforts are also underway with a recently established relationship with Syneos Health (NASDAQ: SYNH).

• Linzagolix for Endometriosis:  The EDELWEISS 3 study in the EU is progressing as planned, with randomization of patients completed and primary endpoint data expected in Q4:2021. The ongoing Phase 3 EDELWEISS 3 study (Europe and US) enrolled 486 patients with endometriosis-associated pain, with a co-primary endpoint of response on both dysmenorrhea (menstrual pain) and non-menstrual pelvic pain. The study includes a 75 mg once-daily dose without hormonal ABT, and a 200 mg once-daily dose in combination with hormonal ABT (1 mg E2 / 0.5mg NETA). Subjects who complete the initial six-month treatment period have the option to enter a six-month treatment extension

• Ebopiprant for Treatment of Preterm Labor:  In Q3:2021, ObsEva granted a license to Organon (NYSE: OGN) for the global development, manufacturing and commercial rights to ebopiprant.  Plans for the further development of ebopiprant are yet to be announced.

• Nolasiban for In Vitro Fertilization:  ObsEva is also advancing nolasiban, an oral oxytocin receptor antagonist, to improve live birth rates in women undergoing in vitro fertilization.

Financial Update

Net income for the quarter ended September 30, 2021 was $0.8 million, or $0.01 per share, compared with a net loss of $24.4 million, or $0.49 per share, for the quarter ended September 30, 2020.  Research and development expenses were $11.5 million and general and administrative expenses were $7.0 million for the quarter ended September 30, 2021, compared with $20.1 million and $3.5 million, respectively, for the corresponding prior year quarter. Net income for the quarter ended September 30, 2021 included non-cash expenses of $1.7 million for stock-based compensation, compared with $1.9 million for stock-based compensation in the corresponding prior year quarter.

As of September 30, 2021, ObsEva had cash and cash equivalents of $62.9 million, compared with $31.2 million as of December 31, 2020.

In October 2021, ObsEva entered into a convertible note financing agreement with certain funds and accounts managed by JGB Management, Inc., which is structured to provide up to $135 million in borrowing capacity, available in nine tranches, subject to certain conditions to funding.  

The third quarter 2021 financial report will be available in the financial reports section of the Company’s website.  

About ObsEva

ObsEva is a biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health and pregnancy. Through strategic in-licensing and disciplined drug development, ObsEva has established a late-stage clinical pipeline with development programs focused on new therapies for the treatment of uterine fibroids, endometriosis, and preterm labor. ObsEva is listed on the Nasdaq Global Select Market and is traded under the ticker symbol “OBSV” and on the SIX Swiss Exchange where it is traded under the ticker symbol “OBSN”. For more information, please visit www.ObsEva.com

Cautionary Note Regarding Forward Looking Statements of ObsEva SA

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as “believe”, “expect”, “may”, “plan”, “potential”, “will”, and similar expressions, and are based on ObsEva’s current beliefs and expectations. These forward-looking statements include expectations regarding the clinical development of and commercialization plans for ObsEva’s product candidates, expectations regarding regulatory and development milestones, including the potential timing of regulatory submissions to the EMA and FDA and ObsEva’s ability to obtain and maintain regulatory approvals for its product candidates, and the results of interactions with regulatory authorities. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the conduct of clinical trials and clinical development, including the risk that the results of earlier clinical trials may not be predictive of the results of later stage clinical trials, related interactions with regulators, ObsEva’s reliance on third parties over which it may not always have full control, and the capabilities of such third parties; the impact of the ongoing novel coronavirus outbreak, and other risks and uncertainties that are described in the Risk Factors section of ObsEva’s Annual Report on Form 20-F for the year ended December 31, 2020 filed with Securities and Exchange Commission (SEC) on March 5, 2021 and other filings ObsEva makes with the SEC. These documents are available on the Investors page of ObsEva’s website at www.ObsEva.com. Any forward-looking statements speak only as of the date of this press release and are based on information available to ObsEva as of the date of this release, and ObsEva assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.

For further information, please contact:

CEO Office Contact:

Shauna Dillon

Shauna.dillon@obseva.ch

+41 22 552 1550

Investor Contact:

Joyce Allaire

jallaire@lifesciadvisors.com

+1 (617) 435-6602

Consolidated Statements of Comprehensive Loss

	Three-Month Period Ended September 30,						Nine-Month Period Ended September 30,
(in USD ’000, except share and per share data) - unaudited	2021			2020			2021			2020
Operating income other than revenue		20,098			3			20,108			11
OPERATING EXPENSES
Research and development expenses		(11,531	)		(20,125	)		(41,532	)		(52,690	)
General and administrative expenses		(7,035	)		(3,514	)		(15,114	)		(9,414	)
Total operating expenses		(18,566	)		(23,639	)		(56,646	)		(62,104	)
OPERATING INCOME / (LOSS)		1,532			(23,636	)		(36,538	)		(62,093	)
Finance income		128			184			702			292
Finance expense		(822	)		(918	)		(2,423	)		(2,619	)
NET INCOME / (LOSS) BEFORE TAX		838			(24,370	)		(38,259	)		(64,420	)
Income tax (expense) / benefit		(19	)		(14	)		(70	)		5
NET INCOME / (LOSS) FOR THE PERIOD		819			(24,384	)		(38,329	)		(64,415	)
Net earnings / (loss) per share
Basic		0.01			(0.49	)		(0.53	)		(1.35	)
Diluted		0.01			(0.49	)		(0.53	)		(1.35	)
Weighted Average Number of Shares Outstanding		77,971,008			50,086,923			74,152,705			47,848,862

Consolidated Balance Sheets

(in USD ’000) - unaudited	September 30, 2021			December 31, 2020
ASSETS
Current assets
Cash and cash equivalents		62,884			31,183
Other receivables		3,428			397
Prepaid expenses		5,746			5,388
Total current assets		72,058			36,968
Non-current assets
Right-of-use assets		730			1,425
Furniture, fixtures and equipment		62			151
Intangible assets		24,503			26,608
Other long-term assets		283			295
Total non-current assets		25,578			28,479
Total assets		97,636			65,447
LIABILITIES AND SHAREHOLDERS’ EQUITY
Current liabilities
Other payables and current liabilities		7,347			10,760
Accrued expenses		10,723			10,248
Current lease liabilities		698			696
Total current liabilities		18,768			21,704
Non-current liabilities
Non-current lease liabilities		383			952
Non-current borrowings		25,623			25,300
Post-employment obligations		8,116			8,218
Other long-term liabilities		577			919
Total non-current liabilities		34,699			35,389
Shareholders’ equity
Share capital		6,948			4,878
Treasury shares		(630	)		(304	)
Share premium		424,561			356,822
Reserves		31,014			26,353
Accumulated losses		(417,724	)		(379,395	)
Total shareholders’ equity		44,169			8,354
Total liabilities and shareholders’ equity		97,636			65,447

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