Note 15 - Commitments and Contingencies (Details Textual) - USD ($)	Feb. 19, 2020	Sep. 12, 2019	May 10, 2018
Qorvo Biotechnologies, LLC [Member]
Development and Supply Agreement, Contingent on Achievement of Future Milestone, First Payment, Cash Only		$ 3,000,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, First Payment, Cash Portion		1,500,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, First Payment, Equity Portion		1,950,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, Second Payment, Cash Only	$ 2,000,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, Third Payment, Cash Only		3,000,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, Third Payment, Cash Portion		1,500,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, Third Payment, Equity Portion		$ 1,950,000
Development and Supply Agreement, Contingent on Achievement of Future Milestone, Fourth Payment, Cash Only	$ 2,000,000
Seraph Biosciences, Inc. [Member]
Development, Commercialization and Exclusive Distribution Agreement, Contingent on Achievement of Development Milestone, Cash			$ 3,500,000
Development, Commercialization and Exclusive Distribution Agreement, Contingent on Achievement of Development Milestone, Equity			$ 3,500,000