ENDRA Life Sciences Inc.

3600 Green Court, Suite 350

Ann Arbor, MI 48105

August 30, 2018

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Attention: Caleb French

Re:

ENDRA Life Sciences Inc.

Registration Statement on Form S-3

File No. 333-226785

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, registrant ENDRA Life Sciences Inc. hereby respectfully requests that the above-referenced Registration Statement on Form S-3 be declared effective at 4:00 p.m., Eastern Time, on Tuesday, September 4, 2018, or as soon thereafter as is practicable.

Please direct any questions regarding this request to Mark Busch of K&L Gates LLP ((704) 331-7440; mark.busch@klgates.com). In addition, please notify Mr. Busch when this request for acceleration has been granted.

Sincerely,

/s/ David Wells

David Wells

Chief Financial Officer