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Related Party Transactions - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Jan. 27, 2016
Jul. 31, 2018
Dec. 31, 2021
Dec. 31, 2020
Related Party Transaction [Line Items]        
Common stock issued for initial consideration for license     771,600  
Research and development expense     $ 83,114,000 $ 87,236,000
License Agreement [Member]        
Related Party Transaction [Line Items]        
Provision for maximum cash payment   $ 2,000,000    
Research and development expense     248,000 381,000
License Agreement [Member] | Stock Purchase Agreement [Member]        
Related Party Transaction [Line Items]        
Common stock issued for initial consideration for license 1,161,665      
Sub-lease Agreement [Member] | Officers and Board Members [Member]        
Related Party Transaction [Line Items]        
Expense related to related party     $ 1,523,000 $ 1,488,000