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Income Taxes - Schedule of Reconciliation of Income Tax Expense (Benefit) (Detail)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]    
Federal income tax expense at statutory rate 21.00% 21.00%
State income taxes, net of federal benefit 6.00% 5.60%
Permanent differences (1.20%) (0.60%)
Foreign rate differential 0.10% 0.10%
Research and development tax credits 2.00% 2.30%
Change in valuation allowance (27.90%) (28.30%)
Provision to Return 0.00% (0.10%)
Effective income tax rate 0.00% 0.00%