Common Stock Warrants and Common Stock Warrant Liability (Tables)

6 Months Ended

Jun. 30, 2022

Common Stock Warrants and Common Stock Warrant Liability [Abstract]

Schedule of common stock warrant activity

						Balance									Balance								Balance
Issue Date	Warrant Type	Term Date	Exercise Price			December 31, 2020		Issued		Exercised			Expired		December 31, 2021		Issued		Exercised		Expired		June 30, 2022
November 21, 2017	Common Stock Offering Warrants	November 21, 2022	$	1.3659	(1)		143,501		-		(21,787	)		-		121,714		-		-		-		121,714
June 20, 2018	Warrant Reissue	December 20, 2023	$	36.40			56,696		-		-			-		56,696		-		-		-		56,696
August 13, 2018	Rights Offering Warrants	July 25, 2023	$	23.00			202,943		-		(499	)		-		202,444		-		-		-		202,444
August 13, 2018	Dealer Manager Warrants	August 13, 2023	$	34.50			13,393		-		-			-		13,393		-		-		-		13,393
July 16, 2019	Dealer Manager Warrants	July 11, 2024	$	33.75			8,334		-		-			-		8,334		-		-		-		8,334
January 28, 2020	Registered Direct Offering	July 28, 2025	$	9.00			177,500		-		-			-		177,500		-		-		-		177,500
January 28, 2020	Dealer Manager Warrants	July 28, 2025	$	10.00			13,315		-		-			-		13,315		-		-		-		13,315
March 6, 2020	Dealer Manager Warrants	March 4, 2025	$	3.76			13,228		-		-			-		13,228		-		-		-		13,228
April 21, 2020	Dealer Manager Warrants	April 21, 2025	$	3.97			118,073		-		-			-		118,073		-		-		-		118,073
April 24, 2020	Registered Direct Offering	April 24, 2025	$	3.05			50,000		-		-			-		50,000		-		-		-		50,000
October 26, 2020	Private Warrant Inducement	April 27, 2026	$	1.73			1,700,680				(700,680	)				1,000,000		-		-		-		1,000,000
October 26, 2020	Dealer Manager Warrants	April 27, 2026	$	2.16			85,034		-							85,034		-		-		-		85,034
February 2, 2021	Private Placement Agreement	August 2, 2026	$	2.216			-		2,194,427		-			-		2,194,427		-		-		-		2,194,427
February 2, 2021	Dealer Manager Warrants	August 2, 2026	$	2.848			-		329,164		-			-		329,164		-		-		-		329,164
March 23, 2021	Dealer Manager Warrants	March 23, 2026	$	2.50			-		148,125		-			-		148,125		-		-		-		148,125
							2,582,697									4,531,447								4,531,447

(1) The initial exercise price of these warrants was $30.00 per share. Pursuant to antidilution price adjustment protection contained within these warrants, the initial exercise price of these warrants was adjusted downward to $29.40 on July 24, 2018, the record date of the 2018 Rights Offering (defined herein) and downward to $19.00 per share on August 13, 2018. These warrants were further adjusted downward from $19.00 to $7.13 and to $2.1122 on January 28, 2020 and March 4, 2020, respectively, in connection with separate Registered Direct Offerings. These warrants were further adjusted downward from $2.1122 to $1.3659 on October 26, 2020 in connection with a Registered Direct Offering. These warrants are subject to further adjustment pursuant to antidilution price adjustment protection.