UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. )*

SHATTUCK LABS, INC.

(Name of Issuer)

Common Stock, $0.0001 par value per share

(Title of Class of Securities)

82024L103

(CUSIP Number)

December 31, 2020

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☐ Rule 13d-1(c)

☒ Rule 13d-1(d)

*    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (the “Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 82024L103

(1)		Names of reporting persons Takeda Pharmaceutical Company Limited
(2)		Check the appropriate box if a member of a group (see instructions) (a) ☐ (b) ☐
(3)		SEC use only
(4)		Citizenship or place of organization Japan
	Number of shares beneficially owned by each reporting person with:			(5)	Sole voting power 0
				(6)	Shared voting power 2,100,312
				(7)	Sole dispositive power 0
				(8)	Shared dispositive power 2,100,312
(9)			Aggregate amount beneficially owned by each reporting person 2,100,312 (1)
(10)			Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ☐
(11)			Percent of class represented by amount in Row (9) 5.06% (2)
(12)			Type of reporting person (see instructions) CO

(1) Takeda Pharmaceutical Company Limited’s beneficial ownership of the Issuer’s Common Stock is comprised of 2,100,312 shares of Common Stock held directly by Millennium Pharmaceuticals, Inc., which is a direct, wholly owned subsidiary of Takeda Pharmaceuticals U.S.A. Inc., which is a direct subsidiary of Takeda Pharmaceutical Company Limited (70.9%), Takeda Pharmaceuticals International AG (27.3%), and Shire Ireland Investment Ltd. (1.8%). Each of Shire Ireland Investment Ltd. and Takeda Pharmaceuticals International AG is a direct, wholly owned subsidiary of Takeda Pharmaceutical Company Limited.

(2) Based on 41,744,237 shares of Common Stock outstanding as reported on the Issuer’s most recent Quarterly Report on Form 10-Q filed with the SEC on November 13, 2020.

Page 2 of 6 pages

CUSIP No. 82024L103

(1)	Names of reporting persons Millennium Pharmaceuticals, Inc.
(2)	Check the appropriate box if a member of a group (see instructions) (a) ☐ (b) ☐
(3)	SEC use only
(4)	Citizenship or place of organization United States
Number of shares beneficially owned by each reporting person with:			(5)	Sole voting power 0
			(6)	Shared voting power 2,100,312
			(7)	Sole dispositive power 0
			(8)	Shared dispositive power 2,100,312
(9)		Aggregate amount beneficially owned by each reporting person 2,100,312
(10)		Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ☐
(11)		Percent of class represented by amount in Row (9) 5.06% (1)
(12)		Type of reporting person (see instructions) CO

(1) Based on 41,744,237 shares of Common Stock outstanding as reported on the Issuer’s most recent Quarterly Report on Form 10-Q filed with the SEC on November 13, 2020.

Page 3 of 6 pages

Item 1(a)    Name of issuer:

Shattuck Labs, Inc.

Item 1(b) Address of issuer’s principal executive offices

1018 W. 11th Street

Suite 100

Austin, TX 78703

Item 2(a)    Name of person filing:

Takeda Pharmaceutical Company Limited

Millennium Pharmaceuticals, Inc.

Item 2(b)    Address of principal business office or, if none, residence:

Takeda Pharmaceutical Company Limited – 1-1, Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo 103-8668, Japan

Millennium Pharmaceuticals, Inc. – 40 Landsdowne Street, Cambridge, MA 02139, USA

Item 2(c)    Citizenship:

Takeda Pharmaceutical Company Limited – Japan

Millennium Pharmaceuticals, Inc. – USA

Item 2(d)    Title of class of securities:

Common Stock

Item 2(e)    CUSIP No.:

82024L103

Item 3.    If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

Not applicable.

Item 4.    Ownership

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned: See the responses to Item 9 on the attached cover pages.

(b) Percent of class: See the responses to Item 11 on the attached cover pages.

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: See the responses to Item 5 on the attached cover pages.

(ii) Shared power to vote or to direct the vote: See the responses to Item 6 on the attached cover pages.

(iii) Sole power to dispose or to direct the disposition of: See the responses to Item 7 on the attached cover pages.

Page 4 of 6 pages

(iv) Shared power to dispose or to direct the disposition of: See the responses to Item 8 on the attached cover pages.

The percentages used herein and in this Item 4 are calculated based on 41,744,237 shares of Common Stock outstanding as reported on the Issuer’s most recent Quarterly Report on Form 10-Q filed with the SEC on November 13, 2020.

Item 5.    Ownership of 5 Percent or Less of a Class.

Not applicable.

Item 6.    Ownership of More than 5 Percent on Behalf of Another Person.

Not applicable.

Item 7.    Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

See Exhibit 99.1.

Item 8.    Identification and Classification of Members of the Group.

Not applicable.

Item 9.    Notice of Dissolution of Group.

Not applicable.

Item 10.    Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Page 5 of 6 pages

Signatures

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: January 29, 2021

TAKEDA PHARMACEUTICAL COMPANY LIMITED
By	/s/ Yoshihiro Nakagawa
	Name:	Yoshihiro Nakagawa
	Title:	Corporate Officer, Global General Counsel

MILLENNIUM PHARMACEUTICALS, INC.
By	/s/ Paul Sundberg
	Name:	Paul Sundberg
	Title:	Attorney-in-fact

Page 6 of 6 pages

INDEX TO EXHIBITS

Exhibit 99.1	Identification of the subsidiary which acquired the security being reported on by the parent holding company
Exhibit 99.2	Joint Filing Agreement
Exhibit 99.3	Power of Attorney