Commitments - Additional Information (Details) $ in Thousands	1 Months Ended		3 Months Ended	12 Months Ended
	Aug. 31, 2022 ft² Extension	Sep. 30, 2021 USD ($) Instalment	Sep. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Other Commitments [Line Items]
Lease renewal period				6 months
Lessee, operating lease, option to extend				the Lease was amended to allow the Company the option to renew the Lease for two 6-month periods. The Company exercised its option to renew the lease for each additional 6 month period during 2022, and the lease term is now extended until December 31, 2023.
Operating lease estimated incremental borrowing rate percent				9.50%
Prepaid rent				$ 5,100
Rent expense				2,100	$ 1,800
Reimbursements for development of lab space				$ 5,500
Reimbursements for development of lab space period				3 years
Reimbursements for development of lab space expiration year				2023
Additional grant for development of lab space			$ 1,000
Grant for development of lab space				$ 3,400
Defined contribution plan, maximum annual contributions per employee, percent				100.00%
Defined contribution plan, employer matching contribution, percent of employee's gross pay				3.00%
Defined contribution plan, employer discretionary contribution amount				$ 600	500
Research and development				92,889	86,778
DarwinHealth
Other Commitments [Line Items]
Estimated years of research collaboration agreement		1 year
Estimated amount of payment over a agreement term		$ 3,000
Number of equal instalments | Instalment		3
Research term		1 year
Research and development					1,000
Grace period following research term for potential refund		18 months
Potential refund receivable from agreement		$ 500
Maximum
Other Commitments [Line Items]
Disbursement incurred costs for lab space				$ 3,400
Maximum | DarwinHealth
Other Commitments [Line Items]
Agreement is eligible to receive payment in future research, development and regulatory milestones		$ 3,000
Operating Lease, until December 31, 2023
Other Commitments [Line Items]
Lease renewal period				6 months
Chestnut Run Lease
Other Commitments [Line Items]
Lease renewal period	5 years
Area of lease premises | ft²	81,000
Initial term of lease	162 months
Number of lease extensions | Extension	3
Chestnut Run Lease | Letter of Credit | Pro Forma
Other Commitments [Line Items]
Security deposit				$ 500
Chestnut Run Lease | Letter of Credit | Silicon Valley Bank
Other Commitments [Line Items]
Security deposit				$ 4,000	$ 4,000