The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   11,570,912 308,311 SH   DFND 2 308,311 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100   500,202 15,700 SH   DFND 2 15,700 0 0
89BIO INC COM 282559103   159,468 13,700 SH   DFND 2 13,700 0 0
ABBOTT LABS COM 002824100   163,009,240 1,434,183 SH   DFND 2 1,434,183 0 0
ABBVIE INC COM 00287Y109   5,024,685 27,593 SH   DFND 2 27,593 0 0
ACCOLADE INC COM 00437E102   6,716,265 640,865 SH   DFND 2 640,865 0 0
ACCOLADE INC COM 00437E102   43,635,042 4,163,649 SH   DFND 3 4,163,649 0 0
ADMA BIOLOGICS INC COM 000899104   269,940 40,900 SH   DFND 2 40,900 0 0
AGILENT TECHNOLOGIES INC COM 00846U101   78,575 540 SH   DFND 2 540 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   175,440 6,000 SH   DFND 2 6,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   116,960,000 4,000,000 SH   DFND 1,2 4,000,000 0 0
ALIGN TECHNOLOGY INC COM 016255101   50,797,759 154,909 SH   DFND 2 154,909 0 0
ALKERMES PLC SHS G01767105   653,578 24,144 SH   DFND 2 24,144 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   1,282,879 8,584 SH   DFND 2 8,584 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   135,954,665 909,700 SH   DFND 1,2 909,700 0 0
ALPHABET INC CAP STK CL C 02079K107   913,560 6,000 SH   DFND 2 6,000 0 0
AMGEN INC COM 031162100   6,294,560 22,139 SH   DFND 2 22,139 0 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105   275,045 45,387 SH   DFND 2 45,387 0 0
ANNEXON INC COM 03589W102   15,647,019 2,182,290 SH   DFND 1,2 2,182,290 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   717,998 12,215 SH   DFND 2 12,215 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   27,138,726 461,700 SH   DFND 3 461,700 0 0
APPLE INC COM 037833100   377,256 2,200 SH   DFND 2 2,200 0 0
ARGENX SE SPONSORED ADR 04016X101   16,148,820 41,016 SH   DFND 2 41,016 0 0
ARGENX SE SPONSORED ADR 04016X101   303,164,400 770,000 SH   DFND 1,2 770,000 0 0
ARVINAS INC COM 04335A105   445,824 10,800 SH   DFND 2 10,800 0 0
ARVINAS INC COM 04335A105   98,246,400 2,380,000 SH   DFND 1,2 2,380,000 0 0
ASTRANA HEALTH INC COM NEW 03763A207   430,649 10,256 SH   DFND 3 10,256 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   1,571,800 23,200 SH   DFND 2 23,200 0 0
ATRICURE INC COM 04963C209   13,609,178 447,376 SH   DFND 3 447,376 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   207,350 32,500 SH   DFND 2 32,500 0 0
AXSOME THERAPEUTICS INC COM 05464T104   287,280 3,600 SH   DFND 2 3,600 0 0
AXSOME THERAPEUTICS INC COM 05464T104   54,413,705 681,876 SH   DFND 3 681,876 0 0
BAIDU INC SPON ADR REP A 056752108   210,560 2,000 SH   DFND 2 2,000 0 0
BAXTER INTL INC COM 071813109   179,508 4,200 SH   DFND 2 4,200 0 0
BEAM THERAPEUTICS INC COM 07373V105   39,420,718 1,193,121 SH   DFND 1,2 1,193,121 0 0
BECTON DICKINSON & CO COM 075887109   102,864,965 415,700 SH   DFND 2 415,700 0 0
BEIGENE LTD SPONSORED ADR 07725L102   3,898,646 24,929 SH   DFND 2 24,929 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   311,250 12,500 SH   DFND 2 12,500 0 0
BIO RAD LABS INC CL A 090572207   54,169,468 156,618 SH   DFND 3 156,618 0 0
BIOGEN INC COM 09062X103   1,295,505 6,008 SH   DFND 2 6,008 0 0
BIOHAVEN LTD COM G1110E107   62,893,500 1,150,000 SH   DFND 1,2 1,150,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   28,104,877 321,787 SH   DFND 2 321,787 0 0
BIOMEA FUSION INC COM 09077A106   266,110 17,800 SH   DFND 2 17,800 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   43,185,444 8,517,839 SH   DFND 1,2 8,517,839 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   483,786 5,100 SH   DFND 2 5,100 0 0
BOSTON SCIENTIFIC CORP COM 101137107   215,652,819 3,148,676 SH   DFND 2 3,148,676 0 0
BRIDGEBIO PHARMA INC COM 10806X102   395,776 12,800 SH   DFND 2 12,800 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   1,270,934 23,436 SH   DFND 2 23,436 0 0
C4 THERAPEUTICS INC COM STK 12529R107   470,592 57,600 SH   DFND 2 57,600 0 0
CARDINAL HEALTH INC COM 14149Y108   335,700 3,000 SH   DFND 2 3,000 0 0
CAREDX INC COM 14167L103   41,661,124 3,934,006 SH   DFND 3 3,934,006 0 0
CASTLE BIOSCIENCES INC COM 14843C105   27,024,883 1,220,085 SH   DFND 3 1,220,085 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   117,373,932 2,796,615 SH   DFND 1,2 2,796,615 0 0
CENCORA INC COM 03073E105   31,954,157 131,504 SH   DFND 2 131,504 0 0
CENTENE CORP DEL COM 15135B101   12,489,857 159,147 SH   DFND 2 159,147 0 0
CENTENE CORP DEL COM 15135B101   16,006,231 203,953 SH   DFND 3 203,953 0 0
CERTARA INC COM 15687V109   1,715,121 95,924 SH   DFND 2 95,924 0 0
CHARLES RIV LABS INTL INC COM 159864107   525,643 1,940 SH   DFND 2 1,940 0 0
CHARLES RIV LABS INTL INC COM 159864107   61,710,759 227,757 SH   DFND 3 227,757 0 0
COOPER COS INC COM 216648501   40,317,465 397,373 SH   DFND 2 397,373 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   678,192 9,950 SH   DFND 2 9,950 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   41,577,600 610,000 SH   DFND 1,2 610,000 0 0
CVS HEALTH CORP COM 126650100   1,759,984 22,066 SH   DFND 2 22,066 0 0
CYTOKINETICS INC COM NEW 23282W605   1,096,520 15,640 SH   DFND 2 15,640 0 0
DANAHER CORPORATION COM 235851102   21,533,855 86,232 SH   DFND 2 86,232 0 0
DEXCOM INC COM 252131107   113,313,739 816,970 SH   DFND 2 816,970 0 0
DEXCOM INC COM 252131107   56,066,285 404,227 SH   DFND 3 404,227 0 0
DOXIMITY INC CL A 26622P107   3,876,789 144,065 SH   DFND 2 144,065 0 0
DR REDDYS LABS LTD ADR 256135203   2,999,722 40,896 SH   DFND 2 40,896 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201   341,995 27,558 SH   DFND 2 27,558 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   89,043,190 931,804 SH   DFND 2 931,804 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   16,372,486 171,332 SH   DFND 3 171,332 0 0
ELEVANCE HEALTH INC COM 036752103   28,752,524 55,449 SH   DFND 2 55,449 0 0
ELEVANCE HEALTH INC COM 036752103   22,381,742 43,163 SH   DFND 3 43,163 0 0
ELI LILLY & CO COM 532457108   45,094,451 57,965 SH   DFND 2 57,965 0 0
ENCOMPASS HEALTH CORP COM 29261A100   1,237,048 14,980 SH   DFND 2 14,980 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   26,650,092 9,944,064 SH   DFND 1,2 9,944,064 0 0
ESSA PHARMA INC COM NEW 29668H708   84,900 10,000 SH   DFND 2 10,000 0 0
ESSA PHARMA INC COM NEW 29668H708   66,897,660 7,879,583 SH   DFND 1,2 7,879,583 0 0
EVOLENT HEALTH INC CL A 30050B101   10,659,898 325,096 SH   DFND 2 325,096 0 0
EVOLENT HEALTH INC CL A 30050B101   37,970,820 1,158,000 SH   DFND 3 1,158,000 0 0
EXACT SCIENCES CORP COM 30063P105   15,808,801 228,914 SH   DFND 2 228,914 0 0
EXACT SCIENCES CORP COM 30063P105   62,817,805 909,612 SH   DFND 3 909,612 0 0
EXELIXIS INC COM 30161Q104   75,936 3,200 SH   DFND 2 3,200 0 0
EXELIXIS INC COM 30161Q104   45,087,000 1,900,000 SH   DFND 1,2 1,900,000 0 0
EXSCIENTIA PLC ADS 30223G102   15,124 2,644 SH   DFND 2 2,644 0 0
FATE THERAPEUTICS INC COM 31189P102   35,523,978 4,839,779 SH   DFND 1,2 4,839,779 0 0
GARMIN LTD SHS H2906T109   416,836 2,800 SH   DFND 2 2,800 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107   46,566,829 512,230 SH   DFND 2 512,230 0 0
GENERATION BIO CO COM 37148K100   15,716,610 3,861,575 SH   DFND 1,2 3,861,575 0 0
GILEAD SCIENCES INC COM 375558103   2,439,591 33,305 SH   DFND 2 33,305 0 0
GLAUKOS CORP COM 377322102   5,273,263 55,926 SH   DFND 2 55,926 0 0
GLOBUS MED INC CL A 379577208   31,105,729 579,898 SH   DFND 2 579,898 0 0
HCA HEALTHCARE INC COM 40412C101   53,265,742 159,703 SH   DFND 2 159,703 0 0
HOLOGIC INC COM 436440101   22,605,983 289,969 SH   DFND 2 289,969 0 0
HUMANA INC COM 444859102   32,543,139 93,860 SH   DFND 2 93,860 0 0
HUMANA INC COM 444859102   14,451,636 41,681 SH   DFND 3 41,681 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   567,336 33,770 SH   DFND 2 33,770 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   18,830,482 1,120,862 SH   DFND 3 1,120,862 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   144,804 3,300 SH   DFND 2 3,300 0 0
IDEXX LABS INC COM 45168D104   50,406,785 93,358 SH   DFND 2 93,358 0 0
ILLUMINA INC COM 452327109   5,986,603 43,596 SH   DFND 2 43,596 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   429,000 6,600 SH   DFND 2 6,600 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   62,767,510 965,654 SH   DFND 1,2 965,654 0 0
INCYTE CORP COM 45337C102   193,014 3,388 SH   DFND 2 3,388 0 0
INCYTE CORP COM 45337C102   122,485,500 2,150,000 SH   DFND 1,2 2,150,000 0 0
INSMED INC COM PAR $.01 457669307   545,313 20,100 SH   DFND 2 20,100 0 0
INSMED INC COM PAR $.01 457669307   57,562,888 2,121,743 SH   DFND 3 2,121,743 0 0
INSPIRE MED SYS INC COM 457730109   18,108,515 84,308 SH   DFND 2 84,308 0 0
INSPIRE MED SYS INC COM 457730109   28,649,979 133,386 SH   DFND 3 133,386 0 0
INSULET CORP COM 45784P101   50,362,119 293,828 SH   DFND 2 293,828 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   1,348,154 19,482 SH   DFND 2 19,482 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   193,760,000 2,800,000 SH   DFND 1,2 2,800,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   244,021,186 611,444 SH   DFND 2 611,444 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   28,232,425 70,742 SH   DFND 3 70,742 0 0
IONIS PHARMACEUTICALS INC COM 462222100   1,712,932 39,514 SH   DFND 2 39,514 0 0
IONIS PHARMACEUTICALS INC COM 462222100   358,071,000 8,260,000 SH   DFND 1,2 8,260,000 0 0
IONQ INC COM 46222L108   11,059 1,107 SH   DFND 2 1,107 0 0
IQVIA HLDGS INC COM 46266C105   2,108,091 8,336 SH   DFND 2 8,336 0 0
JOHNSON & JOHNSON COM 478160104   1,015,580 6,420 SH   DFND 2 6,420 0 0
KRYSTAL BIOTECH INC COM 501147102   855,843 4,810 SH   DFND 2 4,810 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409   32,332 148 SH   DFND 2 148 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   16,449,514 293,270 SH   DFND 2 293,270 0 0
MACROGENICS INC COM 556099109   528,433 35,899 SH   DFND 2 35,899 0 0
MACROGENICS INC COM 556099109   146,169,055 9,929,963 SH   DFND 1,2 9,929,963 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   283,062 1,060 SH   DFND 2 1,060 0 0
MCKESSON CORP COM 58155Q103   4,830,039 8,997 SH   DFND 2 8,997 0 0
MEDTRONIC PLC SHS G5960L103   87,760,050 1,007,000 SH   DFND 2 1,007,000 0 0
MERCK & CO INC COM 58933Y105   41,016,789 310,851 SH   DFND 2 310,851 0 0
MERUS N V COM N5749R100   441,294 9,800 SH   DFND 2 9,800 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105   43,933 33 SH   DFND 2 33 0 0
MICROSOFT CORP COM 594918104   75,730 180 SH   DFND 2 180 0 0
MINERALYS THERAPEUTICS INC COM 603170101   118,772 9,200 SH   DFND 2 9,200 0 0
MODERNA INC COM 60770K107   1,181,644 11,089 SH   DFND 2 11,089 0 0
MODERNA INC COM 60770K107   181,152,000 1,700,000 SH   DFND 1,2 1,700,000 0 0
MOLECULAR TEMPLATES INC COM NEW 608550208   2,306,797 1,029,820 SH   DFND 1,2 1,029,820 0 0
MOLINA HEALTHCARE INC COM 60855R100   41,034,933 99,883 SH   DFND 2 99,883 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   221,012 4,400 SH   DFND 2 4,400 0 0
NATERA INC COM 632307104   24,678,835 269,832 SH   DFND 2 269,832 0 0
NEOGENOMICS INC COM NEW 64049M209   14,871,513 946,025 SH   DFND 3 946,025 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   2,189,342 15,874 SH   DFND 2 15,874 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   281,356,800 2,040,000 SH   DFND 1,2 2,040,000 0 0
NEVRO CORP COM 64157F103   1,952,793 135,235 SH   DFND 2 135,235 0 0
NVIDIA CORPORATION COM 67066G104   87,645 97 SH   DFND 2 97 0 0
OMNIAB INC COM 68218J103   62,092 11,456 SH   DFND 2 11,456 0 0
OMNICELL COM COM 68213N109   6,879,924 235,372 SH   DFND 2 235,372 0 0
OPTION CARE HEALTH INC COM NEW 68404L201   62,628,001 1,867,263 SH   DFND 3 1,867,263 0 0
ORACLE CORP COM 68389X105   85,038 677 SH   DFND 2 677 0 0
OUTSET MED INC COM 690145107   1,270,637 572,359 SH   DFND 2 572,359 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   7,101,694 1,893,785 SH   DFND 2 1,893,785 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   10,119,248 2,698,466 SH   DFND 3 2,698,466 0 0
PENUMBRA INC COM 70975L107   40,430,842 181,158 SH   DFND 2 181,158 0 0
PFIZER INC COM 717081103   938,894 33,834 SH   DFND 2 33,834 0 0
PHREESIA INC COM 71944F106   10,609,150 443,341 SH   DFND 2 443,341 0 0
PRIVIA HEALTH GROUP INC COM 74276R102   20,749,160 1,059,171 SH   DFND 2 1,059,171 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   43,989,434 890,114 SH   DFND 2 890,114 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   553,894 19,146 SH   DFND 2 19,146 0 0
QUALCOMM INC COM 747525103   87,528 517 SH   DFND 2 517 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104   4,239,733 425,249 SH   DFND 2 425,249 0 0
REGENERON PHARMACEUTICALS COM 75886F107   6,811,542 7,077 SH   DFND 2 7,077 0 0
REGENXBIO INC COM 75901B107   252,840 12,000 SH   DFND 2 12,000 0 0
RELAY THERAPEUTICS INC COM 75943R102   13,429 1,618 SH   DFND 2 1,618 0 0
RELAY THERAPEUTICS INC COM 75943R102   49,177,500 5,925,000 SH   DFND 1,2 5,925,000 0 0
RESMED INC COM 761152107   6,018,330 30,391 SH   DFND 2 30,391 0 0
REVOLUTION MEDICINES INC COM 76155X100   866,987 26,900 SH   DFND 2 26,900 0 0
REVOLUTION MEDICINES INC COM 76155X100   162,655,141 5,046,700 SH   DFND 1,2 5,046,700 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   541,625 12,500 SH   DFND 2 12,500 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   530,718 19,700 SH   DFND 2 19,700 0 0
SAGE THERAPEUTICS INC COM 78667J108   90,908 4,851 SH   DFND 2 4,851 0 0
SAGE THERAPEUTICS INC COM 78667J108   83,593,387 4,460,693 SH   DFND 1,2 4,460,693 0 0
SAREPTA THERAPEUTICS INC COM 803607100   453,110 3,500 SH   DFND 2 3,500 0 0
SAREPTA THERAPEUTICS INC COM 803607100   32,108,799 248,021 SH   DFND 3 248,021 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   576,809 32,478 SH   DFND 2 32,478 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   37,877,196 2,132,725 SH   DFND 1,2 2,132,725 0 0
SHOCKWAVE MED INC COM 82489T104   34,447,095 105,786 SH   DFND 2 105,786 0 0
SI-BONE INC COM 825704109   18,661,080 1,139,956 SH   DFND 3 1,139,956 0 0
SILK RD MED INC COM 82710M100   27,813,974 1,518,230 SH   DFND 3 1,518,230 0 0
SIMPLY GOOD FOODS CO COM 82900L102   268,837 7,900 SH   DFND 2 7,900 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   3,483,646 6,660 SH   DFND 2 6,660 0 0
STERIS PLC SHS USD G8473T100   16,509,432 73,434 SH   DFND 2 73,434 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   325,736 7,600 SH   DFND 2 7,600 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   15,272,132 356,326 SH   DFND 3 356,326 0 0
STRYKER CORPORATION COM 863667101   160,805,306 449,340 SH   DFND 2 449,340 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   71,949,154 2,031,888 SH   DFND 3 2,031,888 0 0
TELADOC HEALTH INC COM 87918A105   4,119,250 272,798 SH   DFND 2 272,798 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   446,087 4,244 SH   DFND 2 4,244 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   2,006,625 142,213 SH   DFND 2 142,213 0 0
THE CIGNA GROUP COM 125523100   28,926,268 79,645 SH   DFND 2 79,645 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   23,222,827 39,956 SH   DFND 2 39,956 0 0
TRANSMEDICS GROUP INC COM 89377M109   26,918,892 364,064 SH   DFND 2 364,064 0 0
UNITEDHEALTH GROUP INC COM 91324P102   46,689,786 94,380 SH   DFND 2 94,380 0 0
UNITEDHEALTH GROUP INC COM 91324P102   26,881,503 54,339 SH   DFND 3 54,339 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106   1,043,460 33,000 SH   DFND 2 33,000 0 0
VAXCYTE INC COM 92243G108   904,698 13,244 SH   DFND 2 13,244 0 0
VEEVA SYS INC CL A COM 922475108   38,981,147 168,247 SH   DFND 2 168,247 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   201,125 12,500 SH   DFND 2 12,500 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   18,130,132 1,126,795 SH   DFND 3 1,126,795 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   37,098,388 88,750 SH   DFND 2 88,750 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   242,445,800 580,000 SH   DFND 1,2 580,000 0 0
VERVE THERAPEUTICS INC COM 92539P101   387,776 29,200 SH   DFND 2 29,200 0 0
VIATRIS INC COM 92556V106   173,309 14,515 SH   DFND 2 14,515 0 0
VIKING THERAPEUTICS INC COM 92686J106   442,800 5,400 SH   DFND 2 5,400 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   334,441 19,100 SH   DFND 2 19,100 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   25,262,806 4,094,458 SH   DFND 1,2 4,094,458 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105   344,268 870 SH   DFND 2 870 0 0
XENON PHARMACEUTICALS INC COM 98420N105   607,005 14,100 SH   DFND 2 14,100 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   37,247,000 282,217 SH   DFND 2 282,217 0 0
ZOETIS INC CL A 98978V103   1,270,767 7,510 SH   DFND 2 7,510 0 0