The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 11,570,912 | 308,311 | SH | DFND | 2 | 308,311 | 0 | 0 | ||
4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 500,202 | 15,700 | SH | DFND | 2 | 15,700 | 0 | 0 | ||
89BIO INC | COM | 282559103 | 159,468 | 13,700 | SH | DFND | 2 | 13,700 | 0 | 0 | ||
ABBOTT LABS | COM | 002824100 | 163,009,240 | 1,434,183 | SH | DFND | 2 | 1,434,183 | 0 | 0 | ||
ABBVIE INC | COM | 00287Y109 | 5,024,685 | 27,593 | SH | DFND | 2 | 27,593 | 0 | 0 | ||
ACCOLADE INC | COM | 00437E102 | 6,716,265 | 640,865 | SH | DFND | 2 | 640,865 | 0 | 0 | ||
ACCOLADE INC | COM | 00437E102 | 43,635,042 | 4,163,649 | SH | DFND | 3 | 4,163,649 | 0 | 0 | ||
ADMA BIOLOGICS INC | COM | 000899104 | 269,940 | 40,900 | SH | DFND | 2 | 40,900 | 0 | 0 | ||
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 78,575 | 540 | SH | DFND | 2 | 540 | 0 | 0 | ||
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 175,440 | 6,000 | SH | DFND | 2 | 6,000 | 0 | 0 | ||
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 116,960,000 | 4,000,000 | SH | DFND | 1,2 | 4,000,000 | 0 | 0 | ||
ALIGN TECHNOLOGY INC | COM | 016255101 | 50,797,759 | 154,909 | SH | DFND | 2 | 154,909 | 0 | 0 | ||
ALKERMES PLC | SHS | G01767105 | 653,578 | 24,144 | SH | DFND | 2 | 24,144 | 0 | 0 | ||
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 1,282,879 | 8,584 | SH | DFND | 2 | 8,584 | 0 | 0 | ||
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 135,954,665 | 909,700 | SH | DFND | 1,2 | 909,700 | 0 | 0 | ||
ALPHABET INC | CAP STK CL C | 02079K107 | 913,560 | 6,000 | SH | DFND | 2 | 6,000 | 0 | 0 | ||
AMGEN INC | COM | 031162100 | 6,294,560 | 22,139 | SH | DFND | 2 | 22,139 | 0 | 0 | ||
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 275,045 | 45,387 | SH | DFND | 2 | 45,387 | 0 | 0 | ||
ANNEXON INC | COM | 03589W102 | 15,647,019 | 2,182,290 | SH | DFND | 1,2 | 2,182,290 | 0 | 0 | ||
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 717,998 | 12,215 | SH | DFND | 2 | 12,215 | 0 | 0 | ||
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 27,138,726 | 461,700 | SH | DFND | 3 | 461,700 | 0 | 0 | ||
APPLE INC | COM | 037833100 | 377,256 | 2,200 | SH | DFND | 2 | 2,200 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 16,148,820 | 41,016 | SH | DFND | 2 | 41,016 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 303,164,400 | 770,000 | SH | DFND | 1,2 | 770,000 | 0 | 0 | ||
ARVINAS INC | COM | 04335A105 | 445,824 | 10,800 | SH | DFND | 2 | 10,800 | 0 | 0 | ||
ARVINAS INC | COM | 04335A105 | 98,246,400 | 2,380,000 | SH | DFND | 1,2 | 2,380,000 | 0 | 0 | ||
ASTRANA HEALTH INC | COM NEW | 03763A207 | 430,649 | 10,256 | SH | DFND | 3 | 10,256 | 0 | 0 | ||
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 1,571,800 | 23,200 | SH | DFND | 2 | 23,200 | 0 | 0 | ||
ATRICURE INC | COM | 04963C209 | 13,609,178 | 447,376 | SH | DFND | 3 | 447,376 | 0 | 0 | ||
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 207,350 | 32,500 | SH | DFND | 2 | 32,500 | 0 | 0 | ||
AXSOME THERAPEUTICS INC | COM | 05464T104 | 287,280 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | ||
AXSOME THERAPEUTICS INC | COM | 05464T104 | 54,413,705 | 681,876 | SH | DFND | 3 | 681,876 | 0 | 0 | ||
BAIDU INC | SPON ADR REP A | 056752108 | 210,560 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | ||
BAXTER INTL INC | COM | 071813109 | 179,508 | 4,200 | SH | DFND | 2 | 4,200 | 0 | 0 | ||
BEAM THERAPEUTICS INC | COM | 07373V105 | 39,420,718 | 1,193,121 | SH | DFND | 1,2 | 1,193,121 | 0 | 0 | ||
BECTON DICKINSON & CO | COM | 075887109 | 102,864,965 | 415,700 | SH | DFND | 2 | 415,700 | 0 | 0 | ||
BEIGENE LTD | SPONSORED ADR | 07725L102 | 3,898,646 | 24,929 | SH | DFND | 2 | 24,929 | 0 | 0 | ||
BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 311,250 | 12,500 | SH | DFND | 2 | 12,500 | 0 | 0 | ||
BIO RAD LABS INC | CL A | 090572207 | 54,169,468 | 156,618 | SH | DFND | 3 | 156,618 | 0 | 0 | ||
BIOGEN INC | COM | 09062X103 | 1,295,505 | 6,008 | SH | DFND | 2 | 6,008 | 0 | 0 | ||
BIOHAVEN LTD | COM | G1110E107 | 62,893,500 | 1,150,000 | SH | DFND | 1,2 | 1,150,000 | 0 | 0 | ||
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 28,104,877 | 321,787 | SH | DFND | 2 | 321,787 | 0 | 0 | ||
BIOMEA FUSION INC | COM | 09077A106 | 266,110 | 17,800 | SH | DFND | 2 | 17,800 | 0 | 0 | ||
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 43,185,444 | 8,517,839 | SH | DFND | 1,2 | 8,517,839 | 0 | 0 | ||
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 483,786 | 5,100 | SH | DFND | 2 | 5,100 | 0 | 0 | ||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 215,652,819 | 3,148,676 | SH | DFND | 2 | 3,148,676 | 0 | 0 | ||
BRIDGEBIO PHARMA INC | COM | 10806X102 | 395,776 | 12,800 | SH | DFND | 2 | 12,800 | 0 | 0 | ||
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 1,270,934 | 23,436 | SH | DFND | 2 | 23,436 | 0 | 0 | ||
C4 THERAPEUTICS INC | COM STK | 12529R107 | 470,592 | 57,600 | SH | DFND | 2 | 57,600 | 0 | 0 | ||
CARDINAL HEALTH INC | COM | 14149Y108 | 335,700 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | ||
CAREDX INC | COM | 14167L103 | 41,661,124 | 3,934,006 | SH | DFND | 3 | 3,934,006 | 0 | 0 | ||
CASTLE BIOSCIENCES INC | COM | 14843C105 | 27,024,883 | 1,220,085 | SH | DFND | 3 | 1,220,085 | 0 | 0 | ||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 117,373,932 | 2,796,615 | SH | DFND | 1,2 | 2,796,615 | 0 | 0 | ||
CENCORA INC | COM | 03073E105 | 31,954,157 | 131,504 | SH | DFND | 2 | 131,504 | 0 | 0 | ||
CENTENE CORP DEL | COM | 15135B101 | 12,489,857 | 159,147 | SH | DFND | 2 | 159,147 | 0 | 0 | ||
CENTENE CORP DEL | COM | 15135B101 | 16,006,231 | 203,953 | SH | DFND | 3 | 203,953 | 0 | 0 | ||
CERTARA INC | COM | 15687V109 | 1,715,121 | 95,924 | SH | DFND | 2 | 95,924 | 0 | 0 | ||
CHARLES RIV LABS INTL INC | COM | 159864107 | 525,643 | 1,940 | SH | DFND | 2 | 1,940 | 0 | 0 | ||
CHARLES RIV LABS INTL INC | COM | 159864107 | 61,710,759 | 227,757 | SH | DFND | 3 | 227,757 | 0 | 0 | ||
COOPER COS INC | COM | 216648501 | 40,317,465 | 397,373 | SH | DFND | 2 | 397,373 | 0 | 0 | ||
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 678,192 | 9,950 | SH | DFND | 2 | 9,950 | 0 | 0 | ||
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 41,577,600 | 610,000 | SH | DFND | 1,2 | 610,000 | 0 | 0 | ||
CVS HEALTH CORP | COM | 126650100 | 1,759,984 | 22,066 | SH | DFND | 2 | 22,066 | 0 | 0 | ||
CYTOKINETICS INC | COM NEW | 23282W605 | 1,096,520 | 15,640 | SH | DFND | 2 | 15,640 | 0 | 0 | ||
DANAHER CORPORATION | COM | 235851102 | 21,533,855 | 86,232 | SH | DFND | 2 | 86,232 | 0 | 0 | ||
DEXCOM INC | COM | 252131107 | 113,313,739 | 816,970 | SH | DFND | 2 | 816,970 | 0 | 0 | ||
DEXCOM INC | COM | 252131107 | 56,066,285 | 404,227 | SH | DFND | 3 | 404,227 | 0 | 0 | ||
DOXIMITY INC | CL A | 26622P107 | 3,876,789 | 144,065 | SH | DFND | 2 | 144,065 | 0 | 0 | ||
DR REDDYS LABS LTD | ADR | 256135203 | 2,999,722 | 40,896 | SH | DFND | 2 | 40,896 | 0 | 0 | ||
DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 341,995 | 27,558 | SH | DFND | 2 | 27,558 | 0 | 0 | ||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 89,043,190 | 931,804 | SH | DFND | 2 | 931,804 | 0 | 0 | ||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 16,372,486 | 171,332 | SH | DFND | 3 | 171,332 | 0 | 0 | ||
ELEVANCE HEALTH INC | COM | 036752103 | 28,752,524 | 55,449 | SH | DFND | 2 | 55,449 | 0 | 0 | ||
ELEVANCE HEALTH INC | COM | 036752103 | 22,381,742 | 43,163 | SH | DFND | 3 | 43,163 | 0 | 0 | ||
ELI LILLY & CO | COM | 532457108 | 45,094,451 | 57,965 | SH | DFND | 2 | 57,965 | 0 | 0 | ||
ENCOMPASS HEALTH CORP | COM | 29261A100 | 1,237,048 | 14,980 | SH | DFND | 2 | 14,980 | 0 | 0 | ||
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 26,650,092 | 9,944,064 | SH | DFND | 1,2 | 9,944,064 | 0 | 0 | ||
ESSA PHARMA INC | COM NEW | 29668H708 | 84,900 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | ||
ESSA PHARMA INC | COM NEW | 29668H708 | 66,897,660 | 7,879,583 | SH | DFND | 1,2 | 7,879,583 | 0 | 0 | ||
EVOLENT HEALTH INC | CL A | 30050B101 | 10,659,898 | 325,096 | SH | DFND | 2 | 325,096 | 0 | 0 | ||
EVOLENT HEALTH INC | CL A | 30050B101 | 37,970,820 | 1,158,000 | SH | DFND | 3 | 1,158,000 | 0 | 0 | ||
EXACT SCIENCES CORP | COM | 30063P105 | 15,808,801 | 228,914 | SH | DFND | 2 | 228,914 | 0 | 0 | ||
EXACT SCIENCES CORP | COM | 30063P105 | 62,817,805 | 909,612 | SH | DFND | 3 | 909,612 | 0 | 0 | ||
EXELIXIS INC | COM | 30161Q104 | 75,936 | 3,200 | SH | DFND | 2 | 3,200 | 0 | 0 | ||
EXELIXIS INC | COM | 30161Q104 | 45,087,000 | 1,900,000 | SH | DFND | 1,2 | 1,900,000 | 0 | 0 | ||
EXSCIENTIA PLC | ADS | 30223G102 | 15,124 | 2,644 | SH | DFND | 2 | 2,644 | 0 | 0 | ||
FATE THERAPEUTICS INC | COM | 31189P102 | 35,523,978 | 4,839,779 | SH | DFND | 1,2 | 4,839,779 | 0 | 0 | ||
GARMIN LTD | SHS | H2906T109 | 416,836 | 2,800 | SH | DFND | 2 | 2,800 | 0 | 0 | ||
GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 | 46,566,829 | 512,230 | SH | DFND | 2 | 512,230 | 0 | 0 | ||
GENERATION BIO CO | COM | 37148K100 | 15,716,610 | 3,861,575 | SH | DFND | 1,2 | 3,861,575 | 0 | 0 | ||
GILEAD SCIENCES INC | COM | 375558103 | 2,439,591 | 33,305 | SH | DFND | 2 | 33,305 | 0 | 0 | ||
GLAUKOS CORP | COM | 377322102 | 5,273,263 | 55,926 | SH | DFND | 2 | 55,926 | 0 | 0 | ||
GLOBUS MED INC | CL A | 379577208 | 31,105,729 | 579,898 | SH | DFND | 2 | 579,898 | 0 | 0 | ||
HCA HEALTHCARE INC | COM | 40412C101 | 53,265,742 | 159,703 | SH | DFND | 2 | 159,703 | 0 | 0 | ||
HOLOGIC INC | COM | 436440101 | 22,605,983 | 289,969 | SH | DFND | 2 | 289,969 | 0 | 0 | ||
HUMANA INC | COM | 444859102 | 32,543,139 | 93,860 | SH | DFND | 2 | 93,860 | 0 | 0 | ||
HUMANA INC | COM | 444859102 | 14,451,636 | 41,681 | SH | DFND | 3 | 41,681 | 0 | 0 | ||
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 567,336 | 33,770 | SH | DFND | 2 | 33,770 | 0 | 0 | ||
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 18,830,482 | 1,120,862 | SH | DFND | 3 | 1,120,862 | 0 | 0 | ||
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 144,804 | 3,300 | SH | DFND | 2 | 3,300 | 0 | 0 | ||
IDEXX LABS INC | COM | 45168D104 | 50,406,785 | 93,358 | SH | DFND | 2 | 93,358 | 0 | 0 | ||
ILLUMINA INC | COM | 452327109 | 5,986,603 | 43,596 | SH | DFND | 2 | 43,596 | 0 | 0 | ||
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 429,000 | 6,600 | SH | DFND | 2 | 6,600 | 0 | 0 | ||
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 62,767,510 | 965,654 | SH | DFND | 1,2 | 965,654 | 0 | 0 | ||
INCYTE CORP | COM | 45337C102 | 193,014 | 3,388 | SH | DFND | 2 | 3,388 | 0 | 0 | ||
INCYTE CORP | COM | 45337C102 | 122,485,500 | 2,150,000 | SH | DFND | 1,2 | 2,150,000 | 0 | 0 | ||
INSMED INC | COM PAR $.01 | 457669307 | 545,313 | 20,100 | SH | DFND | 2 | 20,100 | 0 | 0 | ||
INSMED INC | COM PAR $.01 | 457669307 | 57,562,888 | 2,121,743 | SH | DFND | 3 | 2,121,743 | 0 | 0 | ||
INSPIRE MED SYS INC | COM | 457730109 | 18,108,515 | 84,308 | SH | DFND | 2 | 84,308 | 0 | 0 | ||
INSPIRE MED SYS INC | COM | 457730109 | 28,649,979 | 133,386 | SH | DFND | 3 | 133,386 | 0 | 0 | ||
INSULET CORP | COM | 45784P101 | 50,362,119 | 293,828 | SH | DFND | 2 | 293,828 | 0 | 0 | ||
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 1,348,154 | 19,482 | SH | DFND | 2 | 19,482 | 0 | 0 | ||
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 193,760,000 | 2,800,000 | SH | DFND | 1,2 | 2,800,000 | 0 | 0 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 244,021,186 | 611,444 | SH | DFND | 2 | 611,444 | 0 | 0 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 28,232,425 | 70,742 | SH | DFND | 3 | 70,742 | 0 | 0 | ||
IONIS PHARMACEUTICALS INC | COM | 462222100 | 1,712,932 | 39,514 | SH | DFND | 2 | 39,514 | 0 | 0 | ||
IONIS PHARMACEUTICALS INC | COM | 462222100 | 358,071,000 | 8,260,000 | SH | DFND | 1,2 | 8,260,000 | 0 | 0 | ||
IONQ INC | COM | 46222L108 | 11,059 | 1,107 | SH | DFND | 2 | 1,107 | 0 | 0 | ||
IQVIA HLDGS INC | COM | 46266C105 | 2,108,091 | 8,336 | SH | DFND | 2 | 8,336 | 0 | 0 | ||
JOHNSON & JOHNSON | COM | 478160104 | 1,015,580 | 6,420 | SH | DFND | 2 | 6,420 | 0 | 0 | ||
KRYSTAL BIOTECH INC | COM | 501147102 | 855,843 | 4,810 | SH | DFND | 2 | 4,810 | 0 | 0 | ||
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 32,332 | 148 | SH | DFND | 2 | 148 | 0 | 0 | ||
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 16,449,514 | 293,270 | SH | DFND | 2 | 293,270 | 0 | 0 | ||
MACROGENICS INC | COM | 556099109 | 528,433 | 35,899 | SH | DFND | 2 | 35,899 | 0 | 0 | ||
MACROGENICS INC | COM | 556099109 | 146,169,055 | 9,929,963 | SH | DFND | 1,2 | 9,929,963 | 0 | 0 | ||
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 283,062 | 1,060 | SH | DFND | 2 | 1,060 | 0 | 0 | ||
MCKESSON CORP | COM | 58155Q103 | 4,830,039 | 8,997 | SH | DFND | 2 | 8,997 | 0 | 0 | ||
MEDTRONIC PLC | SHS | G5960L103 | 87,760,050 | 1,007,000 | SH | DFND | 2 | 1,007,000 | 0 | 0 | ||
MERCK & CO INC | COM | 58933Y105 | 41,016,789 | 310,851 | SH | DFND | 2 | 310,851 | 0 | 0 | ||
MERUS N V | COM | N5749R100 | 441,294 | 9,800 | SH | DFND | 2 | 9,800 | 0 | 0 | ||
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 43,933 | 33 | SH | DFND | 2 | 33 | 0 | 0 | ||
MICROSOFT CORP | COM | 594918104 | 75,730 | 180 | SH | DFND | 2 | 180 | 0 | 0 | ||
MINERALYS THERAPEUTICS INC | COM | 603170101 | 118,772 | 9,200 | SH | DFND | 2 | 9,200 | 0 | 0 | ||
MODERNA INC | COM | 60770K107 | 1,181,644 | 11,089 | SH | DFND | 2 | 11,089 | 0 | 0 | ||
MODERNA INC | COM | 60770K107 | 181,152,000 | 1,700,000 | SH | DFND | 1,2 | 1,700,000 | 0 | 0 | ||
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 2,306,797 | 1,029,820 | SH | DFND | 1,2 | 1,029,820 | 0 | 0 | ||
MOLINA HEALTHCARE INC | COM | 60855R100 | 41,034,933 | 99,883 | SH | DFND | 2 | 99,883 | 0 | 0 | ||
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 221,012 | 4,400 | SH | DFND | 2 | 4,400 | 0 | 0 | ||
NATERA INC | COM | 632307104 | 24,678,835 | 269,832 | SH | DFND | 2 | 269,832 | 0 | 0 | ||
NEOGENOMICS INC | COM NEW | 64049M209 | 14,871,513 | 946,025 | SH | DFND | 3 | 946,025 | 0 | 0 | ||
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 2,189,342 | 15,874 | SH | DFND | 2 | 15,874 | 0 | 0 | ||
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 281,356,800 | 2,040,000 | SH | DFND | 1,2 | 2,040,000 | 0 | 0 | ||
NEVRO CORP | COM | 64157F103 | 1,952,793 | 135,235 | SH | DFND | 2 | 135,235 | 0 | 0 | ||
NVIDIA CORPORATION | COM | 67066G104 | 87,645 | 97 | SH | DFND | 2 | 97 | 0 | 0 | ||
OMNIAB INC | COM | 68218J103 | 62,092 | 11,456 | SH | DFND | 2 | 11,456 | 0 | 0 | ||
OMNICELL COM | COM | 68213N109 | 6,879,924 | 235,372 | SH | DFND | 2 | 235,372 | 0 | 0 | ||
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 62,628,001 | 1,867,263 | SH | DFND | 3 | 1,867,263 | 0 | 0 | ||
ORACLE CORP | COM | 68389X105 | 85,038 | 677 | SH | DFND | 2 | 677 | 0 | 0 | ||
OUTSET MED INC | COM | 690145107 | 1,270,637 | 572,359 | SH | DFND | 2 | 572,359 | 0 | 0 | ||
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 7,101,694 | 1,893,785 | SH | DFND | 2 | 1,893,785 | 0 | 0 | ||
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 10,119,248 | 2,698,466 | SH | DFND | 3 | 2,698,466 | 0 | 0 | ||
PENUMBRA INC | COM | 70975L107 | 40,430,842 | 181,158 | SH | DFND | 2 | 181,158 | 0 | 0 | ||
PFIZER INC | COM | 717081103 | 938,894 | 33,834 | SH | DFND | 2 | 33,834 | 0 | 0 | ||
PHREESIA INC | COM | 71944F106 | 10,609,150 | 443,341 | SH | DFND | 2 | 443,341 | 0 | 0 | ||
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 20,749,160 | 1,059,171 | SH | DFND | 2 | 1,059,171 | 0 | 0 | ||
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 43,989,434 | 890,114 | SH | DFND | 2 | 890,114 | 0 | 0 | ||
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 553,894 | 19,146 | SH | DFND | 2 | 19,146 | 0 | 0 | ||
QUALCOMM INC | COM | 747525103 | 87,528 | 517 | SH | DFND | 2 | 517 | 0 | 0 | ||
RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 4,239,733 | 425,249 | SH | DFND | 2 | 425,249 | 0 | 0 | ||
REGENERON PHARMACEUTICALS | COM | 75886F107 | 6,811,542 | 7,077 | SH | DFND | 2 | 7,077 | 0 | 0 | ||
REGENXBIO INC | COM | 75901B107 | 252,840 | 12,000 | SH | DFND | 2 | 12,000 | 0 | 0 | ||
RELAY THERAPEUTICS INC | COM | 75943R102 | 13,429 | 1,618 | SH | DFND | 2 | 1,618 | 0 | 0 | ||
RELAY THERAPEUTICS INC | COM | 75943R102 | 49,177,500 | 5,925,000 | SH | DFND | 1,2 | 5,925,000 | 0 | 0 | ||
RESMED INC | COM | 761152107 | 6,018,330 | 30,391 | SH | DFND | 2 | 30,391 | 0 | 0 | ||
REVOLUTION MEDICINES INC | COM | 76155X100 | 866,987 | 26,900 | SH | DFND | 2 | 26,900 | 0 | 0 | ||
REVOLUTION MEDICINES INC | COM | 76155X100 | 162,655,141 | 5,046,700 | SH | DFND | 1,2 | 5,046,700 | 0 | 0 | ||
RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 541,625 | 12,500 | SH | DFND | 2 | 12,500 | 0 | 0 | ||
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 530,718 | 19,700 | SH | DFND | 2 | 19,700 | 0 | 0 | ||
SAGE THERAPEUTICS INC | COM | 78667J108 | 90,908 | 4,851 | SH | DFND | 2 | 4,851 | 0 | 0 | ||
SAGE THERAPEUTICS INC | COM | 78667J108 | 83,593,387 | 4,460,693 | SH | DFND | 1,2 | 4,460,693 | 0 | 0 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 453,110 | 3,500 | SH | DFND | 2 | 3,500 | 0 | 0 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 32,108,799 | 248,021 | SH | DFND | 3 | 248,021 | 0 | 0 | ||
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 576,809 | 32,478 | SH | DFND | 2 | 32,478 | 0 | 0 | ||
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 37,877,196 | 2,132,725 | SH | DFND | 1,2 | 2,132,725 | 0 | 0 | ||
SHOCKWAVE MED INC | COM | 82489T104 | 34,447,095 | 105,786 | SH | DFND | 2 | 105,786 | 0 | 0 | ||
SI-BONE INC | COM | 825704109 | 18,661,080 | 1,139,956 | SH | DFND | 3 | 1,139,956 | 0 | 0 | ||
SILK RD MED INC | COM | 82710M100 | 27,813,974 | 1,518,230 | SH | DFND | 3 | 1,518,230 | 0 | 0 | ||
SIMPLY GOOD FOODS CO | COM | 82900L102 | 268,837 | 7,900 | SH | DFND | 2 | 7,900 | 0 | 0 | ||
SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 3,483,646 | 6,660 | SH | DFND | 2 | 6,660 | 0 | 0 | ||
STERIS PLC | SHS USD | G8473T100 | 16,509,432 | 73,434 | SH | DFND | 2 | 73,434 | 0 | 0 | ||
STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 325,736 | 7,600 | SH | DFND | 2 | 7,600 | 0 | 0 | ||
STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 15,272,132 | 356,326 | SH | DFND | 3 | 356,326 | 0 | 0 | ||
STRYKER CORPORATION | COM | 863667101 | 160,805,306 | 449,340 | SH | DFND | 2 | 449,340 | 0 | 0 | ||
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 71,949,154 | 2,031,888 | SH | DFND | 3 | 2,031,888 | 0 | 0 | ||
TELADOC HEALTH INC | COM | 87918A105 | 4,119,250 | 272,798 | SH | DFND | 2 | 272,798 | 0 | 0 | ||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 446,087 | 4,244 | SH | DFND | 2 | 4,244 | 0 | 0 | ||
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 2,006,625 | 142,213 | SH | DFND | 2 | 142,213 | 0 | 0 | ||
THE CIGNA GROUP | COM | 125523100 | 28,926,268 | 79,645 | SH | DFND | 2 | 79,645 | 0 | 0 | ||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 23,222,827 | 39,956 | SH | DFND | 2 | 39,956 | 0 | 0 | ||
TRANSMEDICS GROUP INC | COM | 89377M109 | 26,918,892 | 364,064 | SH | DFND | 2 | 364,064 | 0 | 0 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 46,689,786 | 94,380 | SH | DFND | 2 | 94,380 | 0 | 0 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 26,881,503 | 54,339 | SH | DFND | 3 | 54,339 | 0 | 0 | ||
VANECK ETF TRUST | GOLD MINERS ETF | 92189F106 | 1,043,460 | 33,000 | SH | DFND | 2 | 33,000 | 0 | 0 | ||
VAXCYTE INC | COM | 92243G108 | 904,698 | 13,244 | SH | DFND | 2 | 13,244 | 0 | 0 | ||
VEEVA SYS INC | CL A COM | 922475108 | 38,981,147 | 168,247 | SH | DFND | 2 | 168,247 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 201,125 | 12,500 | SH | DFND | 2 | 12,500 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 18,130,132 | 1,126,795 | SH | DFND | 3 | 1,126,795 | 0 | 0 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 37,098,388 | 88,750 | SH | DFND | 2 | 88,750 | 0 | 0 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 242,445,800 | 580,000 | SH | DFND | 1,2 | 580,000 | 0 | 0 | ||
VERVE THERAPEUTICS INC | COM | 92539P101 | 387,776 | 29,200 | SH | DFND | 2 | 29,200 | 0 | 0 | ||
VIATRIS INC | COM | 92556V106 | 173,309 | 14,515 | SH | DFND | 2 | 14,515 | 0 | 0 | ||
VIKING THERAPEUTICS INC | COM | 92686J106 | 442,800 | 5,400 | SH | DFND | 2 | 5,400 | 0 | 0 | ||
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 334,441 | 19,100 | SH | DFND | 2 | 19,100 | 0 | 0 | ||
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 25,262,806 | 4,094,458 | SH | DFND | 1,2 | 4,094,458 | 0 | 0 | ||
WEST PHARMACEUTICAL SVSC INC | COM | 955306105 | 344,268 | 870 | SH | DFND | 2 | 870 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 607,005 | 14,100 | SH | DFND | 2 | 14,100 | 0 | 0 | ||
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 37,247,000 | 282,217 | SH | DFND | 2 | 282,217 | 0 | 0 | ||
ZOETIS INC | CL A | 98978V103 | 1,270,767 | 7,510 | SH | DFND | 2 | 7,510 | 0 | 0 |