0000950170-23-039057.txt : 20230807 0000950170-23-039057.hdr.sgml : 20230807 20230807160702 ACCESSION NUMBER: 0000950170-23-039057 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 13 CONFORMED PERIOD OF REPORT: 20230807 ITEM INFORMATION: Results of Operations and Financial Condition ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20230807 DATE AS OF CHANGE: 20230807 FILER: COMPANY DATA: COMPANY CONFORMED NAME: CRISPR Therapeutics AG CENTRAL INDEX KEY: 0001674416 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 473173478 STATE OF INCORPORATION: V8 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 001-37923 FILM NUMBER: 231147639 BUSINESS ADDRESS: STREET 1: BAARERSTRASSE 14 CITY: ZUG STATE: V8 ZIP: CH-6300 BUSINESS PHONE: 6173154600 MAIL ADDRESS: STREET 1: BAARERSTRASSE 14 CITY: ZUG STATE: V8 ZIP: CH-6300 8-K 1 crsp-20230807.htm 8-K 8-K
0001674416false00-000000000016744162023-08-072023-08-07

 

 

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): August 7, 2023

 

 

CRISPR THERAPEUTICS AG

(Exact name of registrant as specified in its charter)

 

 

Switzerland

001-37923

Not Applicable

(State or other jurisdiction
of incorporation)

(Commission File Number)

(IRS Employer
Identification No.)

 

 

 

 

 

Baarerstrasse 14

 

6300 Zug, Switzerland

 

Not Applicable

(Address of principal executive offices)

 

(Zip Code)

 

Registrant’s telephone number, including area code: 41 (0)41 561 32 77

 

 

(Former name or former address, if changed since last report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Securities registered pursuant to Section 12(b) of the Act:


Title of each class

 

Trading
Symbol(s)

 


Name of each exchange on which registered

Common Shares, nominal value CHF 0.03

 

CRSP

 

The NASDAQ Global Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 

 

 


 

Item 2.02 Results of Operations and Financial Condition.

On August 7, 2023, CRISPR Therapeutics AG announced its financial results for the quarter ended June 30, 2023 and other business highlights. The full text of the press release issued in connection with the announcement is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

 

The information in this Form 8-K (including Exhibit 99.1) shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits:

The following exhibits shall be deemed to be furnished, and not filed:

 

Exhibit
No.

 

Description

 

 

99.1

Press Release by CRISPR Therapeutics AG, dated August 7, 2023

104

Cover Page Interactive Data File (embedded within the Inline XBRL document)

 

 


 

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 

 

 

CRISPR Therapeutics AG

 

 

 

 

Date:

August 7, 2023

By:

/s/ Samarth Kulkarni, Ph.D.

 

 

 

Samarth Kulkarni, Ph.D.
Chief Executive Officer

 

 

 


EX-99.1 2 crsp-ex99_1.htm EX-99.1 EX-99.1

Exhibit 99.1

 

CRISPR Therapeutics Provides Business Update and Reports Second Quarter 2023 Financial Results

-FDA accepted Biologics License Applications (BLAs) for exagamglogene autotemcel (exa-cel) for severe Sickle Cell Disease (SCD) and Transfusion-Dependent Beta Thalassemia (TDT); Priority Review for SCD and Standard Review for TDT-

-PDUFA target action date of December 8, 2023, for SCD and March 30, 2024, for TDT-

-Enrollment and dosing ongoing for CTX110®, targeting CD19+ B-cell malignancies, and CTX130™, targeting CD70 for the treatment of T cell lymphomas-

-Enrollment ongoing and dosing initiated for next generation CAR T candidates, CTX112™ targeting CD19+ B-cell malignancies and CTX131™ targeting CD70+ solid tumors-

-Enrollment and dosing ongoing in a Phase 1/2 clinical trial of VCTX211™ for the treatment of Type 1 Diabetes (T1D)-

 

-Continues to advance its lead in vivo program, CTX310™, targeting angiopoietin-related protein 3 (ANGPTL3), into the clinic this year-

 

ZUG, Switzerland and BOSTON, Mass., August 7, 2023 – CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today reported financial results for the second quarter ended June 30, 2023.

“The second quarter of 2023 was a period of continued substantial progress toward our goal of delivering innovative gene edited therapies to patients, including the FDA’s acceptance of the exa-cel BLAs for SCD and TDT and the presentation of updated interim exa-cel trial data at EHA, which demonstrated transformative, consistent and durable benefit to patients,” said Samarth Kulkarni, Ph.D., Chief Executive Officer of CRISPR Therapeutics. “In parallel, we continue to advance our various clinical programs rapidly, including our next-generation CAR T candidates. In addition, we plan to initiate a clinical trial for CTX310, our lead
in vivo program targeting ANGPTL3, this year. All together, we are well-positioned to realize our mission of bringing transformative and potentially curative therapies to patients in need and look forward to continued momentum in the months ahead.”

 

Recent Highlights and Outlook

Hemoglobinopathies
o
In June, CRISPR Therapeutics and Vertex Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) accepted the Biologics License Applications (BLAs) for the investigational treatment exagamglogene autotemcel (exa-cel) for severe sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). The FDA has granted Priority Review for SCD and Standard Review for TDT and assigned Prescription Drug User Fee Act (PDUFA) target action dates of December 8, 2023, and March 30, 2024, respectively. The FDA has indicated that it plans to hold an advisory committee meeting for exa-cel. In the U.S., exa-cel has been granted Fast Track, Regenerative Medicine Advanced Therapy (RMAT), Orphan Drug and Rare Pediatric Disease designations.
o
Additionally, in the fourth quarter of 2022, CRISPR Therapeutics and Vertex completed regulatory submissions for exa-cel in the EU and the United Kingdom, and the European Medicines Agency (EMA), and the Medicines and Healthcare products Regulatory Agency (MHRA), are reviewing the regulatory submissions for exa-cel in SCD and TDT. In the EU, exa-cel has been granted Orphan Drug Designation from the European Commission, as well as PRIME designation from the EMA for the treatment of both TDT and SCD. In the United Kingdom, exa-cel has been granted an Innovation Passport under the Innovative Licensing and Access Pathway from the MHRA.

o
In June, CRISPR Therapeutics and Vertex Pharmaceuticals presented positive interim results from the pivotal trials of exa-cel in SCD and TDT at the 2023 Annual European Hematology Association (EHA) Congress. Both trials met the primary and key secondary endpoints at pre-specified interim analyses, and the data continue to demonstrate transformative, consistent and durable benefit. The data presented at EHA were the basis of the EMA and MHRA regulatory filings for exa-cel. CRISPR Therapeutics and Vertex expect to present updated clinical data that served as the basis of the FDA filing at a future medical congress.
o
The Phase 1/2/3 CLIMB-111 and CLIMB-121 studies and the CLIMB-131 long-term follow-up study are ongoing in patients 12 years of age and older.
o
Two global Phase 3 studies of exa-cel continue to enroll and dose patients 5 to 11 years of age with TDT or SCD.
o
CRISPR Therapeutics continues to advance its anti-CD117 (c-Kit) antibody-drug conjugate (ADC), its internal targeted conditioning program, in pre-clinical studies. This targeted conditioning agent has the potential to significantly expand the patient population that can benefit from exa-cel.

 

Immuno-Oncology
o
CRISPR Therapeutics continues to enroll and dose patients in a Phase 2 single-arm potentially registrational clinical trial of CTX110®, its wholly-owned allogeneic chimeric antigen receptor T cell (CAR T) investigational therapy targeting CD19+ B-cell malignancies. Based on encouraging preliminary data, CTX110 was granted RMAT designation by the FDA.
o
CRISPR Therapeutics continues to enroll and dose patients in the Phase 1 COBALT™-LYM trial evaluating the safety and efficacy of CTX130™, its wholly-owned allogeneic CAR T cell therapy targeting CD70 for the treatment of relapsed or refractory T cell malignancies. Based on encouraging preliminary data, CTX130 was granted RMAT designation by the FDA.
o
CRISPR Therapeutics continues to enroll and has initiated dosing in a Phase 1 clinical trial of CTX112™, its next generation CAR T candidate targeting CD19+ B-cell malignancies. CTX112 incorporates the edits in CTX110 plus additional edits to the genes encoding Regnase-1 and transforming growth factor-beta (TGF-β) receptor type 2 (TGFBR2), which have been shown to increase CAR T potency and reduce CAR T exhaustion in pre-clinical studies. In addition, CRISPR Therapeutics continues to enroll patients and has initiated dosing patients in a Phase 1 clinical trial of CTX131™, its next generation CAR T cell candidate targeting CD70, following clearance of its IND application by the FDA in February 2023. CTX131 incorporates the edits in CTX130 plus additional edits to the genes encoding Regnase-1 and TGFBR2.

 

Regenerative Medicine
o
In March, CRISPR Therapeutics and Vertex and CRISPR Therapeutics and ViaCyte, Inc., which was acquired by Vertex in 2022, entered into agreements relating to the research, development, manufacturing and commercialization of therapeutic products in the diabetes field, including a new non-exclusive licensing agreement for the use of CRISPR Therapeutics’ CRISPR/Cas9 gene editing technology to accelerate the development of Vertex’s hypoimmune cell therapies for type 1 diabetes (T1D). In connection with entering into the agreements with Vertex and ViaCyte, CRISPR Therapeutics received $100 million up-front from Vertex and will be eligible for up to an additional $230 million in research and development milestones and receive royalties on any future products resulting from the non-exclusive licensing agreement. As part of the licensing agreement, a research milestone was achieved in the second quarter of 2023, triggering a payment of $70 million to be received by CRISPR Therapeutics in the third quarter of 2023.
o
CRISPR Therapeutics and ViaCyte continue to collaborate on their existing gene-edited allogeneic stem cell therapies for the treatment of diabetes under the terms of their collaboration. Enrollment and dosing are ongoing in a Phase 1/2 clinical trial of VCTX211TM for the treatment of T1D.

In Vivo
o
CRISPR Therapeutics continues to build out its in vivo platform, focused on lipid nanoparticle (LNP)-based delivery to the liver and extrahepatic tissues. The Company is advancing multiple in vivo programs directed towards cardiovascular indications and beyond.
o
CRISPR Therapeutics remains on track to advance its lead in vivo program, CTX310™, targeting angiopoietin-related protein 3 (ANGPTL3) into the clinic this year. Natural history studies showing that individuals with natural loss-of-function variants of ANGPTL3 have lower triglyceride levels, lower LDL-C levels, and a lower risk of coronary artery disease validate targeting ANGPTL3 for the treatment of atherosclerotic cardiovascular disease (ASCVD).
o
Additionally, CRISPR Therapeutics is advancing an investigational program targeting lipoprotein (a) (Lp(a)) and expects to enter the clinic in the first half of 2024. High levels of Lp(a) are an independent and causal risk factor for ASCVD. CTX310 and CTX320 have the potential to shift the treatment paradigm for ASCVD with a single-dose, potentially life-long durable editing approach.
o
Beyond CTX310 and CTX320, CRISPR Therapeutics is advancing additional programs utilizing in vivo delivery to address both rare and common diseases.

 

Second Quarter 2023 Financial Results

Cash & Accounts Receivable: Cash, cash equivalents, marketable securities and accounts receivables were $1,843.0 million as of June 30, 2023, compared to $1,868.4 million as of December 31, 2022. The decrease in cash and accounts receivable of $25.4 million was primarily driven by operating expenses, offset by the $100.0 million upfront payment received from Vertex in connection with a non-exclusive license agreement in the first quarter of 2023 and $70.0 million receivable resulting from a research milestone achieved during the current quarter.
Revenue: Total collaboration revenue was $70.0 million for the quarter ended June 30, 2023. Collaboration revenue for the second quarter of 2022 was not material. Collaboration revenue recognized in the second quarter of 2023 was primarily attributable to a research milestone achieved during the current quarter in connection with a non-exclusive license agreement with Vertex.
R&D Expenses: R&D expenses were $101.6 million for the second quarter of 2023, compared to $123.2 million for the second quarter of 2022. The decrease in R&D expense was primarily driven by reduced variable external research and manufacturing costs.
G&A Expenses: General and administrative expenses were $19.0 million for the second quarter of 2023, compared to $26.3 million for the second quarter of 2022. The decrease in G&A expense was primarily driven by a decrease in external professional costs.
Collaboration Expense: Collaboration expense, net, was $44.6 million for the second quarter of 2023, compared to $33.9 million for the second quarter of 2022. The increase in collaboration expense, net, was primarily driven by an increase in manufacturing and pre-commercial costs associated with the exa-cel program.
Net Loss: Net loss was $77.7 million for the second quarter of 2023, compared to a net loss of $185.8 million for the second quarter of 2022.

 

About exagamglogene autotemcel (exa-cel)

Exa-cel, formerly known as CTX001, is an investigational, autologous, ex vivo CRISPR/Cas9 gene-edited therapy that is being evaluated for patients with TDT or SCD characterized by recurrent vaso-occlusive crises (VOCs), in which a patient’s own hematopoietic stem cells are edited to produce high levels of fetal hemoglobin (HbF; hemoglobin F) in red blood cells. HbF is the form of the oxygen-carrying hemoglobin that is naturally present during fetal development, which then switches to the adult form of hemoglobin after birth. The elevation of HbF by exa-cel has the potential to alleviate transfusion


requirements for patients with TDT and reduce painful and debilitating sickle crises for patients with SCD. Earlier results from these ongoing trials were published in The New England Journal of Medicine in January of 2021.

 

Based on progress in this program to date, exa-cel has been granted Regenerative Medicine Advanced Therapy (RMAT), Fast Track, Orphan Drug, and Rare Pediatric Disease designations from the FDA for both TDT and SCD. Exa-cel has also been granted Orphan Drug Designation from the European Commission, as well as Priority Medicines (PRIME) designation from the European Medicines Agency (EMA), for both TDT and SCD. In the U.K., exa-cel has been granted an Innovation Passport under the Innovative Licensing and Access Pathway (ILAP) from the MHRA.


About CLIMB-111 and CLIMB-121

The ongoing Phase 1/2/3 open-label trials, CLIMB-111 and CLIMB-121, are designed to assess the safety and efficacy of a single dose of exa-cel in patients ages 12 to 35 years with TDT or with SCD, characterized by recurrent VOCs, respectively. The trials are now closed for enrollment. Patients will be followed for approximately two years after exa-cel infusion. Each patient will be asked to participate in CLIMB-131, a long-term follow-up trial.

About CLIMB-131

This is a long-term, open-label trial to evaluate the safety and efficacy of exa-cel in patients who received exa-cel in CLIMB-111, CLIMB-121, CLIMB-141 or CLIMB-151. The trial is designed to follow participants for up to 15 years after exa-cel infusion.

About CLIMB-141 and CLIMB-151

The ongoing Phase 3 open-label trials, CLIMB-141 and CLIMB-151, are designed to assess the safety and efficacy of a single dose of exa-cel in patients ages 2 to 11 years with TDT or with SCD, characterized by recurrent VOCs, respectively. The trials are now open for enrollment and currently enrolling patients ages 5 to 11 years of age and will plan to extend to patients 2 to less than 5 years of age at a later date. Each trial will enroll approximately 12 patients. Patients will be followed for approximately two years after infusion. Each patient will be asked to participate in CLIMB-131, a long-term follow-up- trial.

About the CRISPR-Vertex Collaboration

CRISPR Therapeutics and Vertex Pharmaceuticals entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. Exa-cel represents the first potential treatment to emerge from the joint research program. Under an amended collaboration agreement, Vertex now leads global development, manufacturing and commercialization of exa-cel and splits program costs and profits worldwide 60/40 with CRISPR Therapeutics.

About CTX110 and CTX112

CTX110, a wholly owned program of CRISPR Therapeutics, is a healthy donor-derived gene-edited allogeneic CAR T investigational therapy targeting cluster of differentiation 19, or CD19. CTX110 is being investigated in the ongoing CARBON clinical trial, which is designed to assess the safety and efficacy of CTX110 in adult patients with relapsed or refractory CD19-positive B-cell malignancies who have received at least two prior lines of therapy. CTX110 has been granted RMAT designation by the FDA. In addition, CTX112, a next-generation allogeneic CAR T cell therapy targeting CD19, is being investigated in a clinical trial. CTX112 incorporates additional edits designed to enhance CAR T potency and reduce CAR T exhaustion.

About CTX130 and CTX131

CTX130, a wholly owned program of CRISPR Therapeutics, is a healthy donor-derived gene-edited allogeneic CAR T investigational therapy targeting cluster of differentiation 70, or CD70, an antigen expressed on various solid tumors and hematologic malignancies. CTX130 is being investigated for the treatment of relapsed or refractory T-cell hematologic malignancies in the COBALT-LYM trial and for renal cell carcinoma in the COBALT-RCC trial. CTX130 has been granted Orphan Drug designation for the treatment of T cell lymphoma by the FDA and RMAT designation for the treatment of relapsed or refractory Mycosis Fungoides and Sézary Syndrome (MF/SS), types of cutaneous T cell lymphoma (CTCL). In addition, CTX131, a next-generation allogeneic CAR T cell therapy targeting CD70, is being assessed for safety and efficacy


in a clinical trial investigating a basket of select solid tumors. CTX131 incorporates additional edits designed to enhance CAR T potency and reduce CAR T exhaustion.

About VCTX211

VCTX211 is an allogeneic, gene-edited, stem cell-derived investigational therapy for the treatment of T1D, which incorporates additional gene edits that aim to further enhance cell fitness. This immune-evasive cell replacement therapy is designed to enable patients to produce their own insulin in response to glucose.

About CRISPR Therapeutics

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and cardiometabolic diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom. For more information, please visit www.crisprtx.com.

CRISPR THERAPEUTICS® standard character mark and design logo, COBALT™, CTX001™, CTX110®, CTX112™, CTX130™, CTX131™, CTX310™, CTX320™, VCTX211™ are trademarks and registered trademarks of CRISPR Therapeutics AG. All other trademarks and registered trademarks are the property of their respective owners.

CRISPR Therapeutics Forward-Looking Statement

This press release may contain a number of “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements made by Dr. Kulkarni in this press release, as well as statements regarding CRISPR Therapeutics’ expectations about any or all of the following: (i) its preclinical studies, clinical trials and pipeline products and programs, including, without limitation, status of such studies and trials, expected timing of data releases, timing of regulatory submissions and the regulatory filings for exa-cel; (ii) the sufficiency of its cash resources; (iii) the expected benefits of its collaborations; and (iv) the therapeutic value, development, and commercial potential of CRISPR/Cas9 gene editing technologies and therapies. Without limiting the foregoing, the words “believes,” “anticipates,” “plans,” “expects” and similar expressions are intended to identify forward-looking statements. You are cautioned that forward-looking statements are inherently uncertain. Although CRISPR Therapeutics believes that such statements are based on reasonable assumptions within the bounds of its knowledge of its business and operations, forward-looking statements are neither promises nor guarantees and they are necessarily subject to a high degree of uncertainty and risk. Actual performance and results may differ materially from those projected or suggested in the forward-looking statements due to various risks and uncertainties. These risks and uncertainties include, among others: the potential for preliminary data from any clinical trial not to be indicative of final trial results; the potential that clinical trial results may not be favorable; that one or more of its internal or external product candidate programs will not proceed as planned for technical, scientific or commercial reasons; that future competitive or other market factors may adversely affect the commercial potential for its product candidates; uncertainties inherent in the initiation and completion of preclinical studies for its product candidates and whether results from such studies will be predictive of future results of future studies or clinical trials; uncertainties about regulatory approvals to conduct trials or to market products; it may not realize the potential benefits of its collaborations; uncertainties regarding the intellectual property protection for its technology and intellectual property belonging to third parties, and the outcome of proceedings (such as an interference, an opposition or a similar proceeding) involving all or any portion of such intellectual property; and those risks and uncertainties described under the heading "Risk Factors" in CRISPR Therapeutics’ most recent annual report on Form 10-K, quarterly report on Form 10-Q and in any other subsequent filings made by CRISPR Therapeutics with the U.S. Securities and Exchange Commission, which are available on the SEC's website at www.sec.gov. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. CRISPR Therapeutics disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law.

 


Investor Contact:
Susan Kim
+1-617-307-7503
susan.kim@crisprtx.com

Media Contact:
Rachel Eides
+1-617-315-4493
rachel.eides@crisprtx.com

 


CRISPR Therapeutics AG

Condensed Consolidated Statements of Operations

(Unaudited, In thousands except share data and per share data)

 

 

 

Three Months Ended June 30,

 

 

Six Months Ended June 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

Revenue:

 

 

 

 

 

 

 

 

 

 

 

 

Collaboration revenue

 

$

70,000

 

 

$

158

 

 

$

170,000

 

 

$

336

 

Grant revenue

 

 

 

 

 

 

 

 

 

 

 

762

 

Total revenue

 

$

70,000

 

 

$

158

 

 

$

170,000

 

 

$

1,098

 

Operating expenses:

 

 

 

 

 

 

 

 

 

 

 

 

Research and development

 

 

101,555

 

 

 

123,223

 

 

 

201,490

 

 

 

241,468

 

General and administrative

 

 

19,032

 

 

 

26,273

 

 

 

41,392

 

 

 

54,294

 

Collaboration expense, net

 

 

44,636

 

 

 

33,922

 

 

 

86,828

 

 

 

64,568

 

Total operating expenses

 

 

165,223

 

 

 

183,418

 

 

 

329,710

 

 

 

360,330

 

Loss from operations

 

 

(95,223

)

 

 

(183,260

)

 

 

(159,710

)

 

 

(359,232

)

Total other income, net

 

 

18,406

 

 

 

3,544

 

 

 

31,148

 

 

 

3,907

 

Net loss before income taxes

 

 

(76,817

)

 

 

(179,716

)

 

 

(128,562

)

 

 

(355,325

)

Provision for income taxes

 

 

(923

)

 

 

(6,118

)

 

 

(2,243

)

 

 

(9,726

)

Net loss

 

 

(77,740

)

 

 

(185,834

)

 

 

(130,805

)

 

 

(365,051

)

Foreign currency translation adjustment

 

 

28

 

 

 

(69

)

 

 

60

 

 

 

(95

)

Unrealized gain (loss) on marketable securities

 

 

452

 

 

 

(3,380

)

 

 

6,679

 

 

 

(15,180

)

Comprehensive loss

 

$

(77,260

)

 

$

(189,283

)

 

$

(124,066

)

 

$

(380,326

)

Net loss per common share — basic

 

$

(0.98

)

 

$

(2.40

)

 

$

(1.66

)

 

$

(4.72

)

Basic weighted-average common shares outstanding

 

 

79,091,061

 

 

 

77,513,327

 

 

 

78,885,168

 

 

 

77,306,970

 

Net loss per common share — diluted

 

$

(0.98

)

 

$

(2.40

)

 

$

(1.66

)

 

$

(4.72

)

Diluted weighted-average common shares outstanding

 

 

79,091,061

 

 

 

77,513,327

 

 

 

78,885,168

 

 

 

77,306,970

 

 

 

CRISPR Therapeutics AG

Condensed Consolidated Balance Sheets Data

(Unaudited, in thousands)

 

 

 

As of

 

 

 

June 30, 2023

 

 

December 31, 2022

 

Cash and cash equivalents

 

$

444,796

 

 

$

211,885

 

Marketable securities

 

 

1,323,307

 

 

 

1,603,433

 

Marketable securities, non-current

 

 

4,901

 

 

 

53,130

 

Working capital

 

 

1,726,735

 

 

 

1,731,919

 

Total assets

 

 

2,197,014

 

 

 

2,243,057

 

Total shareholders' equity

 

 

1,816,028

 

 

 

1,875,479

 

 


EX-101.PRE 3 crsp-20230807_pre.xml XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE DOCUMENT EX-101.SCH 4 crsp-20230807.xsd XBRL TAXONOMY EXTENSION SCHEMA DOCUMENT 100000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink EX-101.LAB 5 crsp-20230807_lab.xml XBRL TAXONOMY EXTENSION LABEL LINKBASE DOCUMENT Pre-commencement Issuer Tender Offer Trading Symbol Soliciting Material Entity Address, City or Town Written Communications Entity Central Index Key Entity Tax Identification Number Entity Registrant Name Document Period End Date Entity Address, Postal Zip Code Entity Incorporation, State or Country Code Local Phone Number City Area Code Pre-commencement Tender Offer Cover [Abstract] Security Exchange Name Entity Emerging Growth Company Amendment Flag Securities Act File Number Entity Address, Address Line One Title of 12(b) Security Entity Address, Country Document Type XML 6 R1.htm IDEA: XBRL DOCUMENT v3.23.2
Document and Entity Information
Aug. 07, 2023
Cover [Abstract]  
Entity Tax Identification Number 00-0000000
Amendment Flag false
Entity Central Index Key 0001674416
Document Type 8-K
Document Period End Date Aug. 07, 2023
Entity Registrant Name CRISPR THERAPEUTICS AG
Entity Incorporation, State or Country Code V8
Securities Act File Number 001-37923
Entity Address, Address Line One Baarerstrasse 14
Entity Address, Postal Zip Code 6300
Entity Address, City or Town Zug
Entity Address, Country CH
City Area Code 41 (0)41
Local Phone Number 561 32 77
Written Communications false
Soliciting Material false
Pre-commencement Tender Offer false
Pre-commencement Issuer Tender Offer false
Title of 12(b) Security Common Shares, nominal value CHF 0.03
Trading Symbol CRSP
Security Exchange Name NASDAQ
Entity Emerging Growth Company false
XML 7 crsp-20230807_htm.xml IDEA: XBRL DOCUMENT 0001674416 2023-08-07 2023-08-07 0001674416 false 00-0000000 8-K 2023-08-07 CRISPR THERAPEUTICS AG V8 001-37923 Baarerstrasse 14 6300 Zug CH 41 (0)41 561 32 77 false false false false Common Shares, nominal value CHF 0.03 CRSP NASDAQ false EXCEL 8 Financial_Report.xlsx IDEA: XBRL DOCUMENT begin 644 Financial_Report.xlsx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end XML 9 Show.js IDEA: XBRL DOCUMENT // Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission. Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105. var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0); e.removeAttribute('id');a.parentNode.appendChild(e)}} if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'} e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}} XML 10 report.css IDEA: XBRL DOCUMENT /* Updated 2009-11-04 */ /* v2.2.0.24 */ /* DefRef Styles */ ..report table.authRefData{ background-color: #def; border: 2px solid #2F4497; font-size: 1em; position: absolute; } ..report table.authRefData a { display: block; font-weight: bold; } ..report table.authRefData p { margin-top: 0px; } ..report table.authRefData .hide { background-color: #2F4497; padding: 1px 3px 0px 0px; text-align: right; } ..report table.authRefData .hide a:hover { background-color: #2F4497; } ..report table.authRefData .body { height: 150px; overflow: auto; width: 400px; } ..report table.authRefData table{ font-size: 1em; } /* Report Styles */ ..pl a, .pl a:visited { color: black; text-decoration: none; } /* table */ ..report { background-color: white; border: 2px solid #acf; clear: both; color: black; font: normal 8pt Helvetica, Arial, san-serif; margin-bottom: 2em; } ..report hr { border: 1px solid #acf; } /* Top labels */ ..report th { background-color: #acf; color: black; font-weight: bold; text-align: center; } ..report th.void { background-color: transparent; color: #000000; font: bold 10pt Helvetica, Arial, san-serif; text-align: left; } ..report .pl { text-align: left; vertical-align: top; white-space: normal; width: 200px; white-space: normal; /* word-wrap: break-word; */ } ..report td.pl a.a { cursor: pointer; display: block; width: 200px; overflow: hidden; } ..report td.pl div.a { width: 200px; } ..report td.pl a:hover { background-color: #ffc; } /* Header rows... */ ..report tr.rh { background-color: #acf; color: black; font-weight: bold; } /* Calendars... */ ..report .rc { background-color: #f0f0f0; } /* Even rows... */ ..report .re, .report .reu { background-color: #def; } ..report .reu td { border-bottom: 1px solid black; } /* Odd rows... */ ..report .ro, .report .rou { background-color: white; } ..report .rou td { border-bottom: 1px solid black; } ..report .rou table td, .report .reu table td { border-bottom: 0px solid black; } /* styles for footnote marker */ ..report .fn { white-space: nowrap; } /* styles for numeric types */ ..report .num, .report .nump { text-align: right; white-space: nowrap; } ..report .nump { padding-left: 2em; } ..report .nump { padding: 0px 0.4em 0px 2em; } /* styles for text types */ ..report .text { text-align: left; white-space: normal; } ..report .text .big { margin-bottom: 1em; width: 17em; } ..report .text .more { display: none; } ..report .text .note { font-style: italic; font-weight: bold; } ..report .text .small { width: 10em; } ..report sup { font-style: italic; } ..report .outerFootnotes { font-size: 1em; } XML 11 FilingSummary.xml IDEA: XBRL DOCUMENT 3.23.2 html 1 22 1 false 0 0 false 0 false false R1.htm 100000 - Document - Document and Entity Information Sheet http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation Document and Entity Information Cover 1 false false All Reports Book All Reports crsp-20230807.htm crsp-20230807.xsd crsp-20230807_lab.xml crsp-20230807_pre.xml crsp-ex99_1.htm http://xbrl.sec.gov/dei/2023 true false JSON 13 MetaLinks.json IDEA: XBRL DOCUMENT { "instance": { "crsp-20230807.htm": { "axisCustom": 0, "axisStandard": 0, "baseTaxonomies": { "http://xbrl.sec.gov/dei/2023": 22 }, "contextCount": 1, "dts": { "inline": { "local": [ "crsp-20230807.htm" ] }, "labelLink": { "local": [ "crsp-20230807_lab.xml" ] }, "presentationLink": { "local": [ "crsp-20230807_pre.xml" ] }, "schema": { "local": [ "crsp-20230807.xsd" ], "remote": [ "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd", "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd", "http://www.xbrl.org/2003/xl-2003-12-31.xsd", "http://www.xbrl.org/2003/xlink-2003-12-31.xsd", "http://www.xbrl.org/2005/xbrldt-2005.xsd", "http://www.xbrl.org/2006/ref-2006-02-27.xsd", "https://www.xbrl.org/2020/extensible-enumerations-2.0.xsd", "https://www.xbrl.org/dtr/type/2020-01-21/types.xsd", "https://www.xbrl.org/dtr/type/2022-03-31/types.xsd", "https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd", "https://xbrl.fasb.org/srt/2023/elts/srt-roles-2023.xsd", "https://xbrl.fasb.org/srt/2023/elts/srt-types-2023.xsd", "https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd", "https://xbrl.fasb.org/us-gaap/2023/elts/us-roles-2023.xsd", "https://xbrl.fasb.org/us-gaap/2023/elts/us-types-2023.xsd", "https://xbrl.sec.gov/country/2023/country-2023.xsd", "https://xbrl.sec.gov/dei/2023/dei-2023.xsd" ] } }, "elementCount": 23, "entityCount": 1, "hidden": { "http://xbrl.sec.gov/dei/2023": 3, "total": 3 }, "keyCustom": 0, "keyStandard": 22, "memberCustom": 0, "memberStandard": 0, "nsprefix": "crsp", "nsuri": "http://www.crisprtx.com/20230807", "report": { "R1": { "firstAnchor": { "ancestors": [ "span", "p", "body", "html" ], "baseRef": "crsp-20230807.htm", "contextRef": "C_a00d1857-b387-4952-a252-62d2a165ef35", "decimals": null, "first": true, "lang": "en-US", "name": "dei:DocumentType", "reportCount": 1, "unique": true, "unitRef": null, "xsiNil": "false" }, "groupType": "document", "isDefault": "true", "longName": "100000 - Document - Document and Entity Information", "menuCat": "Cover", "order": "1", "role": "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation", "shortName": "Document and Entity Information", "subGroupType": "", "uniqueAnchor": { "ancestors": [ "span", "p", "body", "html" ], "baseRef": "crsp-20230807.htm", "contextRef": "C_a00d1857-b387-4952-a252-62d2a165ef35", "decimals": null, "first": true, "lang": "en-US", "name": "dei:DocumentType", "reportCount": 1, "unique": true, "unitRef": null, "xsiNil": "false" } } }, "segmentCount": 0, "tag": { "dei_AmendmentFlag": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.", "label": "Amendment Flag" } } }, "localname": "AmendmentFlag", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_CityAreaCode": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Area code of city", "label": "City Area Code" } } }, "localname": "CityAreaCode", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_CoverAbstract": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Cover page.", "label": "Cover [Abstract]" } } }, "localname": "CoverAbstract", "nsuri": "http://xbrl.sec.gov/dei/2023", "xbrltype": "stringItemType" }, "dei_DocumentPeriodEndDate": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.", "label": "Document Period End Date" } } }, "localname": "DocumentPeriodEndDate", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "dateItemType" }, "dei_DocumentType": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.", "label": "Document Type" } } }, "localname": "DocumentType", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "submissionTypeItemType" }, "dei_EntityAddressAddressLine1": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Address Line 1 such as Attn, Building Name, Street Name", "label": "Entity Address, Address Line One" } } }, "localname": "EntityAddressAddressLine1", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressCityOrTown": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Name of the City or Town", "label": "Entity Address, City or Town" } } }, "localname": "EntityAddressCityOrTown", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressCountry": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "ISO 3166-1 alpha-2 country code.", "label": "Entity Address, Country" } } }, "localname": "EntityAddressCountry", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "countryCodeItemType" }, "dei_EntityAddressPostalZipCode": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Code for the postal or zip code", "label": "Entity Address, Postal Zip Code" } } }, "localname": "EntityAddressPostalZipCode", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityCentralIndexKey": { "auth_ref": [ "r1" ], "lang": { "en-us": { "role": { "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.", "label": "Entity Central Index Key" } } }, "localname": "EntityCentralIndexKey", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "centralIndexKeyItemType" }, "dei_EntityEmergingGrowthCompany": { "auth_ref": [ "r1" ], "lang": { "en-us": { "role": { "documentation": "Indicate if registrant meets the emerging growth company criteria.", "label": "Entity Emerging Growth Company" } } }, "localname": "EntityEmergingGrowthCompany", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_EntityFileNumber": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.", "label": "Securities Act File Number" } } }, "localname": "EntityFileNumber", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "fileNumberItemType" }, "dei_EntityIncorporationStateCountryCode": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Two-character EDGAR code representing the state or country of incorporation.", "label": "Entity Incorporation, State or Country Code" } } }, "localname": "EntityIncorporationStateCountryCode", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "edgarStateCountryItemType" }, "dei_EntityRegistrantName": { "auth_ref": [ "r1" ], "lang": { "en-us": { "role": { "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.", "label": "Entity Registrant Name" } } }, "localname": "EntityRegistrantName", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityTaxIdentificationNumber": { "auth_ref": [ "r1" ], "lang": { "en-us": { "role": { "documentation": "The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.", "label": "Entity Tax Identification Number" } } }, "localname": "EntityTaxIdentificationNumber", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "employerIdItemType" }, "dei_LocalPhoneNumber": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Local phone number for entity.", "label": "Local Phone Number" } } }, "localname": "LocalPhoneNumber", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_PreCommencementIssuerTenderOffer": { "auth_ref": [ "r3" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.", "label": "Pre-commencement Issuer Tender Offer" } } }, "localname": "PreCommencementIssuerTenderOffer", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_PreCommencementTenderOffer": { "auth_ref": [ "r4" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.", "label": "Pre-commencement Tender Offer" } } }, "localname": "PreCommencementTenderOffer", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_Security12bTitle": { "auth_ref": [ "r0" ], "lang": { "en-us": { "role": { "documentation": "Title of a 12(b) registered security.", "label": "Title of 12(b) Security" } } }, "localname": "Security12bTitle", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "securityTitleItemType" }, "dei_SecurityExchangeName": { "auth_ref": [ "r2" ], "lang": { "en-us": { "role": { "documentation": "Name of the Exchange on which a security is registered.", "label": "Security Exchange Name" } } }, "localname": "SecurityExchangeName", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "edgarExchangeCodeItemType" }, "dei_SolicitingMaterial": { "auth_ref": [ "r5" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.", "label": "Soliciting Material" } } }, "localname": "SolicitingMaterial", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_TradingSymbol": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Trading symbol of an instrument as listed on an exchange.", "label": "Trading Symbol" } } }, "localname": "TradingSymbol", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "tradingSymbolItemType" }, "dei_WrittenCommunications": { "auth_ref": [ "r6" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.", "label": "Written Communications" } } }, "localname": "WrittenCommunications", "nsuri": "http://xbrl.sec.gov/dei/2023", "presentation": [ "http://www.crisprtx.com/20230807/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" } }, "unitCount": 0 } }, "std_ref": { "r0": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b", "role": "http://www.xbrl.org/2003/role/presentationRef" }, "r1": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b-2", "role": "http://www.xbrl.org/2003/role/presentationRef" }, "r2": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "d1-1", "role": "http://www.xbrl.org/2003/role/presentationRef" }, "r3": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "13e", "Subsection": "4c", "role": "http://www.xbrl.org/2003/role/presentationRef" }, "r4": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "14d", "Subsection": "2b", "role": "http://www.xbrl.org/2003/role/presentationRef" }, "r5": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "14a", "Subsection": "12", "role": "http://www.xbrl.org/2003/role/presentationRef" }, "r6": { "Name": "Securities Act", "Number": "230", "Publisher": "SEC", "Section": "425", "role": "http://www.xbrl.org/2003/role/presentationRef" } }, "version": "2.2" } ZIP 14 0000950170-23-039057-xbrl.zip IDEA: XBRL DOCUMENT begin 644 0000950170-23-039057-xbrl.zip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end