Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 683,906	$ 923,031
Marketable securities	1,537,355	1,456,098
Accounts receivable	143	305
Prepaid expenses and other current assets	39,212	38,079
Total current assets	2,260,616	2,417,513
Property and equipment, net	157,453	137,575
Intangible assets, net	112	125
Restricted cash	12,123	16,913
Operating lease assets	171,541	174,460
Other non-current assets	4,330	5,291
Total assets	2,606,175	2,751,877
Current liabilities:
Accounts payable	27,111	14,816
Accrued expenses	72,632	91,003
Deferred revenue, current		1,011
Accrued tax liabilities	2,608	724
Operating lease liabilities	11,076	12,158
Other current liabilities	270	171
Total current liabilities	113,697	119,883
Deferred revenue, non-current	12,323	12,323
Operating lease liabilities, net of current portion	227,904	212,872
Other non-current liabilities	7,335	7,339
Total liabilities	361,259	352,417
Commitments and contingencies, see Note 6
Shareholders’ equity:
Common shares, CHF 0.03 par value, 145,364,335 shares authorized at March 31, 2022 and December 31, 2021, 77,566,721 and 77,170,382 shares issued at March 31,2022 and December 31, 2021, respectively, 77,386,405 and 76,990,066 shares outstanding at March 31,2022 and December 31, 2021, respectively.	2,407	2,391
Treasury shares, at cost, 180,316 shares at March 31, 2022 and at December 31, 2021	(63)	(63)
Additional paid-in capital	2,634,597	2,598,114
Accumulated deficit	(375,132)	(195,915)
Accumulated other comprehensive loss	(16,893)	(5,067)
Total shareholders' equity	2,244,916	2,399,460
Total liabilities and shareholders’ equity	$ 2,606,175	$ 2,751,877