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Income tax, Components of income tax, Geographical classification (Details) - GBP (£)
£ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Current tax [Abstract]      
Current tax £ (1,406) £ (8,952) £ (12,448)
Deferred tax [Abstract]      
Deferred tax (1,515) (453) (819)
Total income tax credit (2,921) (9,405) (13,267)
United States [Member]      
Current tax [Abstract]      
Federal 692 106 (16)
State 75 0 0
Deferred tax [Abstract]      
Federal (1,488) (453) (819)
State 0 0 0
United Kingdom [Member]      
Current tax [Abstract]      
Current tax (2,173) (9,058) (12,432)
Deferred tax [Abstract]      
Deferred tax 0 0 0
Ireland [Member]      
Current tax [Abstract]      
Current tax 0 0 0
Deferred tax [Abstract]      
Deferred tax £ (27) £ 0 £ 0