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Accounting policies, Going concern (Details)
1 Months Ended 12 Months Ended
Jul. 31, 2022
GBP (£)
Jul. 31, 2022
USD ($)
Dec. 31, 2022
GBP (£)
Dec. 31, 2021
GBP (£)
Dec. 31, 2020
GBP (£)
Dec. 31, 2019
GBP (£)
Going concern [Abstract]            
Cash and cash equivalents     £ 332,539,000 £ 237,886,000 £ 129,716,000 £ 73,966,000
Net current assets     308,791,000      
Operating loss     (39,607,000) (135,162,000) (86,193,000)  
Product revenue, net     108,148,000 0 0  
Pre-product revenue, net     £ 8,661,000 £ 3,010,000 £ 0  
Proceeds from shares issued £ 116,812,000 $ 140,000,000        
Offering expenses £ 388,000