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Share-Based Compensation - Additional Information (Details)
1 Months Ended 3 Months Ended 9 Months Ended
Jun. 08, 2020
shares
Jan. 03, 2019
USD ($)
$ / shares
shares
Oct. 12, 2018
shares
Jan. 01, 2018
shares
Jun. 30, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
Jun. 30, 2019
USD ($)
$ / shares
shares
Mar. 31, 2017
shares
Sep. 30, 2020
USD ($)
Sep. 30, 2019
USD ($)
Sep. 30, 2020
USD ($)
shares
Sep. 30, 2019
USD ($)
May 31, 2019
shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Share-based compensation expense | $                 $ 6,763,000 $ 7,243,000 $ 21,499,000 $ 21,902,000  
Unrecognized compensation cost of options and RSUs | $                 $ 34,300,000   $ 34,300,000    
Expected to be recognized over a weighted average period                     1 year 8 months 1 day    
Options | General and Administrative Expenses                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Share-based compensation expense | $           $ 900,000              
Options | Elizabeth Barrett                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Option to purchase of ordinary shares   277,432                      
Exercise price of option to purchase of ordinary shares | $ / shares   $ 47.57                      
Options | Non-employee Directors                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Options granted, expected term         10 years   10 years            
Awards vesting period         1 year   1 year            
Number of stock options approved for grants         70,000   70,000            
Stock options granted         10,000   10,000            
Exercise of option to ordinary shares conversion ratio         1   1            
Stock option exercise | $ / shares         $ 28.24   $ 34.83            
Estimated fair value of options granted | $         $ 1,500,000   $ 1,900,000            
Options | Chairman of Board of Directors                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Stock options granted         10,000   10,000            
Options | Tranche One                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Vesting percentage                     33.00%    
Restricted Stock Units (RSUs)                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Awards vesting period                     2 years    
Share-based compensation expense | $           $ 0              
Restricted Stock Units (RSUs) | Elizabeth Barrett                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Option to purchase of ordinary shares   317,065                      
Restricted Stock Units (RSUs) | Tranche One                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Vesting percentage                     33.00%    
2017 Equity Incentive Plan                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Maximum number of ordinary share issuable under the 2017 incentive plan               1,400,000     5,600,000    
Number of ordinary shares reserved for issuance, percentage                     12.00%    
Increase in number of ordinary share issuable under the 2017 incentive plan 400,000   1,900,000 250,167                  
Stock Options and Restricted Stock Units (RSUs) | Elizabeth Barrett                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Fair value | $   $ 24,100,000                      
Plan | Options                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Awards vesting period                     3 years    
Combined voting power percentage                     10.00%    
Ordinary Shares | 2019 Inducement Plan                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Number of stock options approved for grants                         900,000
Ordinary Shares | 2017 Equity Incentive Plan                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Maximum number of ordinary share issuable under the 2017 incentive plan 3,950,167   3,550,167 1,650,167                  
Maximum | Plan | Options                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Options granted, expected term                     10 years    
Minimum | Plan | Options                          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                          
Exercise price of stock options as percentage of fair market value of shares on grant date                     100.00%    
Stock options exercise price percentage for individuals possesses more than 10% of the combined voter power                     110.00%