Summary of Employee and Non-Employee Stock-Based Compensation Expense

The following table summarizes employee and non-employee stock-based compensation expense for the three and six months ended June 30, 2023 and 2022 and the allocation within the condensed consolidated statements of operations and comprehensive loss (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
General and administrative expense	$	946	$	3,267	$	2,069	$	7,699
Research and development expense		375		1,784		734		6,593
Total stock-based compensation	$	1,321	$	5,051	$	2,803	$	14,292

Activity for service-based stock options under the Quince 2019 Plan is as follows:


	Number of Options and Unvested Shares			Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
								(In thousands)
Balance at December 31, 2022		3,319,711		$	16.07		4.77	$	65
Options granted		1,559,958			0.95	—		—
Options exercised		(189,799	)		0.43	—			162
Options cancelled / forfeited		(1,549,075	)		15.13	—		—
Balance at June 30, 2023		3,140,795		$	9.97		7.61	$	814
Options vested and expected to vest as of June 30, 2023		3,140,795			9.97		7.61		814
Options exercisable as of June 30, 2023		1,316,814		$	19.77		5.13	$	154

Summary of Stock Options Activity

Activity for service-based stock options under the 2019 Novosteo Plan is as follows:


	Number of Options and Unvested Shares			Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
								(In thousands)
Balance at December 31, 2022		503,105		$	0.55		9.23	$	44
Options granted		—			—		—		—
Options exercised		(3,027	)		0.55		—		3
Options cancelled / forfeited		(37,848	)		0.55		—		—
Balance at June 30, 2023		462,230		$	0.55		8.73	$	441
Options vested and expected to vest as of June 30, 2023		462,230			0.55		8.73		441
Options exercisable as of June 30, 2023		144,444		$	0.55		8.73	$	138

Summary of Stock Options Activity

Activity for service-based stock options under the 2022 Inducement Plan is as follows:


	Number of Options and Unvested Shares			Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
								(In thousands)
Balance at December 31, 2022		3,742,255		$	2.98		9.39	$	—
Options granted		—			—		—		—
Options exercised		—			—		—		—
Options cancelled / forfeited		(43,500	)		2.98		—		—
Balance at June 30, 2023		3,698,755		$	2.98		8.90	$	—
Options vested and expected to vest as of June 30, 2023		3,698,755			2.98		8.90		—
Options exercisable as of June 30, 2023		1,001,745		$	2.98		8.90	$	—

Summary of Stock Options Activity

The following table summarizes activity under the Company’s RSUs from the Quince 2019 Plan and related information:


	Quince 2019 Plan
	Restricted Stock Units Outstanding
	Number of Shares			Weighted Average Grant Date Fair Value
Unvested - December 31, 2022		30,876		$	4.30
RSUs granted		—		—
RSUs vested		(7,225	)	$	4.30
RSUs cancelled		(19,188	)	$	4.30
Unvested - June 30, 2023		4,463		$	4.30

Summary of Stock Options Activity

Restricted Stock Awards


	Restricted Stock Awards Outstanding
	Number of Shares			Weighted Average Grant Date Fair Value
Unvested - December 31, 2022		427,401		$	3.30
RSAs granted		—		—
RSAs vested		(76,803	)		3.30
RSAs cancelled		(8,536	)		3.30
Unvested - June 30, 2023		342,062		$	3.30