Loss Per Share (Tables)

12 Months Ended

Dec. 31, 2021

Schedule of Computation of Diluted Net Loss Per Share Attributable to Common Stockholders

	Years Ended December 31,
	2021		2020		2019
Series Seed Preferred Stock		—		—		474,298
Series A Preferred Stock		—		—		12,941,857
Options to purchase common stock		5,983,425		5,029,364		2,310,886
Warrant to purchase common stock		—		338,784		—
		5,983,425		5,368,148		15,727,041

Schedule of Basic and Diluted Loss Per Share

All redeemable, convertible preferred stock, including those that were outstanding as of December 31, 2019, as shown above, were converted to shares of the Company’s common stock and effected for a one-for-8.4335 reverse stock split. As described in Note 9, Long-term debt and warrant – related party, in May 2021, Perceptive exercised its warrant using the net exercise method provided by the Credit Agreement.

Basic and diluted loss per share is computed by dividing net loss attributable to common stockholders by the weighted-average common shares outstanding (in thousands, except share and per share data):

	Years Ended December 31,
	2021			2020			2019
Numerator:
Net loss	$	(83,892	)	$	(66,335	)	$	(34,099	)
Accrual of preferred stock dividends		—			—			(8,468	)
Net loss attributable to common stockholders—basic and diluted	$	(83,892	)	$	(66,335	)	$	(42,567	)
Denominator:
Weighted-average common stock outstanding—basic and diluted		46,041,733			11,370,328			1,371,905
Net loss per share attributable to common stockholders—basic and diluted	$	(1.82	)	$	(5.83	)	$	(31.03	)