April 8, 2019

Arthur O. Tziannabos
President and Chief Executive Officer
Homology Medicines, Inc.
One Patriots Park
Bedford, MA 01730

       Re: Homology Medicines, Inc.
           Registration Statement on Form S-3
           Filed April 1, 2019
           File No. 333-230664

Dear Dr. Tziannabos:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Christine Westbrook at 202-551-5019 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Healthcare & Insurance
cc:    Wesley C. Holmes, Esq.