Hancock Jaffe Laboratories, Inc.

70 Doppler

Irvine, California 92618

November 27, 2020

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporate Finance

100 F Street, N.E.

Mail Stop 4628

Washington, DC 20549

Attn: Alan Campbell

Re:	Hancock Jaffe Laboratories, Inc.
	Registration Statement on Form S-1
	Filed November 6, 2020
	File No. 333-249942

Dear Mr. Campbell:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Hancock Jaffe Laboratories, Inc. hereby requests acceleration of effectiveness of the above referenced Registration Statement so that it will become effective at 4:00 p.m. EST on Monday, November 30, 2020, or as soon as thereafter practicable.

Very truly yours,

/s/ Robert A. Berman

By: Robert A. Berman

Title: Chief Executive Officer

cc: Ellenoff Grossman & Schole LLP