0001437749-24-016162.txt : 20240513 0001437749-24-016162.hdr.sgml : 20240513 20240513105322 ACCESSION NUMBER: 0001437749-24-016162 CONFORMED SUBMISSION TYPE: 8-K/A PUBLIC DOCUMENT COUNT: 16 CONFORMED PERIOD OF REPORT: 20240513 ITEM INFORMATION: Results of Operations and Financial Condition ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20240513 DATE AS OF CHANGE: 20240513 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Moleculin Biotech, Inc. CENTRAL INDEX KEY: 0001659617 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] ORGANIZATION NAME: 03 Life Sciences IRS NUMBER: 474671997 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K/A SEC ACT: 1934 Act SEC FILE NUMBER: 001-37758 FILM NUMBER: 24937498 BUSINESS ADDRESS: STREET 1: 5300 MEMORIAL DRIVE STREET 2: SUITE 950 CITY: HOUSTON STATE: TX ZIP: 77007 BUSINESS PHONE: 713-300-5160 MAIL ADDRESS: STREET 1: 5300 MEMORIAL DRIVE STREET 2: SUITE 950 CITY: HOUSTON STATE: TX ZIP: 77007 8-K/A 1 mbrx20240513_8ka.htm FORM 8-K/A mbrx20240513_8ka.htm
Form 8-K/A date of report 05-13-24 true 0001659617 0001659617 2024-05-13 2024-05-13
 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
 
FORM 8-K/A
 
CURRENT REPORT
 
PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934
 
DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): May 13, 2024
 
logo.jpg
 
MOLECULIN BIOTECH, INC.
(Exact Name of Registrant as Specified in its Charter)
 
Delaware
001-37758
47-4671997
(State or Other Jurisdiction of Incorporation
or Organization)
(Commission File No.)
(I.R.S. Employer Identification No.)
 
5300 Memorial Drive, Suite 950, Houston, TX 77007
(Address of principal executive offices and zip code)
 
(713) 300-5160
(Registrant’s telephone number, including area code)
(Former name or former address, if changed from last report)
 
 
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
 
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-14(c))
 
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).  Emerging growth company 
 
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
 
Securities registered pursuant to Section 12(b) of the Act:
 
Title of each class
Trading Symbol (s)
Name of each exchange on which registered
Common Stock, par value $.001 per share
MBRX
The NASDAQ Stock Market LLC
 
 

 
 
EXPLANATORY NOTE
 
On May 13, 2024, Moleculin Biotech, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended March 31, 2024 and recent operational highlights, which was included as Exhibit 99.1 to a Current Report on Form 8-K (the "Original Report") furnished with the U.S. Securities and Exchange Commission on such date. This Current Report (this "Report") on Form 8-K/A is being filed to correct typographical errors in Exhibit 99.1 to the Company's expected milestones included in the Original Report.
 
Item 2.02
Results of Operations and Financial Condition.
 
On May 13, 2024, Moleculin Biotech, Inc. issued an updated press release announcing its financial results for the quarter ended March 31, 2024 and recent operational highlights. A copy of the updated press release is attached to this report as Exhibit 99.1 and is incorporated by reference herein.
 
Item 9.01
Financial Statements and Exhibits.
 
(d)     Exhibits.
 
Exhibit
No.
Description
 
 
99.1
 
 
104
Cover page Interactive Data File (embedded within the Inline XBRL document)
 
SIGNATURE
 
Pursuant to the requirements of the Securities and Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
 
 
MOLECULIN BIOTECH, INC.
   
   
 
Date:  May 13, 2024
   
 
By:  /s/ Jonathan P. Foster 
 
Jonathan P. Foster
 
Chief Financial Officer
 
 
EX-99.1 2 ex_672442.htm EXHIBIT 99.1 ex_672442.htm

Exhibit 99.1

 

logo.jpg

 

Moleculin Reports First Quarter 2024 Financial Results and Provides Corporate Update

 

 

Recently announced interim data from ongoing MB-106 study demonstrating Annamycin in combination with Cytarabine (AnnAraC) achieves CRc rate of 62% (54% CR) in 1st and 2nd line AML subjects (N=13)

 

 

Also announced MB-106 reaches 20 subjects enrolled

 

 

Company to host conference call and webcast today, Monday, May 13th at 8:30 AM ET

 

HOUSTON, May 13, 2024 /PRNewswire/ -- Moleculin Biotech, Inc., (Nasdaq: MBRX) (“Moleculin” or the “Company”), a clinical stage pharmaceutical company with a broad portfolio of drug candidates targeting hard-to-treat tumors and viruses, today reported its financial results for the quarter ended March 31, 2024. As previously announced, the Company will host a conference call and live audio webcast to discuss the operational and financial results at 8:30 AM ET on Monday, May 13, 2024. (details below).

 

“We recently hosted a virtual AML Clinical Day featuring renowned KOLs, Dr. Martin Tallman and Dr. Michael Andreeff. It was great to hear their support of and thoughts on Annamycin’s recent developments in AML. You can hear that discussion here. Combined with the encouraging Annamycin data demonstrated to date and the positive feedback from the KOLs, we continue to believe that our results in 2nd line subjects fill a significant unmet need. We believe this is supported by the exceptional CRc rate demonstrated by AnnAraC in 2nd line patients, which substantially exceeds the performance reported by any drug currently approved in the U.S. for use in 2nd line AML. We believe we are well-positioned for a highly productive End of Phase 2 meeting with FDA to discuss our planned pivotal study of Annamycin for AML,” commented Walter Klemp, Chairman and Chief Executive Officer of Moleculin.

 

Recent Highlights

 

 

Bolstered the patent estate with issuance of U.S. patents. We recently received an Issue Notification from the United States Patent and Trademark Office (USPTO) for U.S. Patent number 11,980,634 titled, “Method of Reconstituting Liposomal Annamycin.” Earlier, we received an Issue Notification titled, “Preparation of Preliposomal Annamycin Lyophilizate.” Both provide claims to compositions that contain Annamycin with a base patent term extending until mid-2040.

 

 

 

 

Hosted a virtual AML clinical day highlighting positive interim data for Annamycin from its ongoing acute myeloid leukemia (AML) clinical development program.

 

o

Full MB-106 trial reaches 20 subjects with CRc of 45% in 1st – 7th line, with median durability at 4.9 months and climbing.

 

o

1st and 2nd line patients reached a CRc rate of 62% and a CR rate of 54%.

 

o

The 2nd line performance from the combination of Annamycin with Ara-C (AnnAraC) exceeds the approval data for all currently approved 2nd line drugs.

 

o

Interim data supports advancement to development of Phase 2 registration-directed clinical trial (MB-108) to further provide data for efficacy to support an eventual application for New Drug Approval (NDA).

 

Announced the formation of its Annamycin Scientific Advisory Board and inaugural appointment of Dr. Martin Tallman.

 

Granted Orphan Drug Designation of Annamycin for the treatment of AML from the European Medicines Agency (EMA), adding to US Orphan Drug and Fast Track designations.

 

Presented positive data demonstrating high anti-cancer activity of Annamycin and non-cardiotoxic properties at the American Association for Cancer Research (AACR) Annual Meeting.

 

Ongoing AML Clinical Trial Summary

 

The Company is currently conducting its Phase 1B/2 clinical trial evaluating Annamycin in combination with Cytarabine (also known as “Ara-C” and for which the combination of Annamycin and Ara-C is referred to as AnnAraC) for the treatment of subjects with AML as both first line therapy and for subjects who are refractory to or relapsed after induction therapy (MB-106). clinicaltrialsregister.eu: EudraCT 2020-005493-10 or clinicaltrials.gov: NCT05319587.

 

A summary table of the MB-106 preliminary results is shown below. These subjects had 0-6 prior therapies. The preliminary data for MB-106 demonstrate a CRc rate of 45% and an overall remission rate (ORR) of 55% for all subjects, regardless of the number of prior treatments (N=20). Segmenting the MB-106 subject population for 1st line (N=3) and, most notably, 2nd line (N=10) therapies in the trial, yields a CRc rate of 67% and 60% and an ORR of 67% and 70%, both respectively.

 

Table 1 - Summary of Annamycin Remissions in MB-106 as of May 2, 2024

 

Study MB-106 Combination Therapy –

Phase 1B/2 with
Ara-C + Annamycin "5+3"

All Lines (Range 1-7)

1st Line

2nd Line

1st and 2nd Line

Combined

All Subjects

       

Recruited and Evaluable

20

3

10

13

Subjects Evaluable Not Dosed Per Protocol

2

0

1

1

Median Age - Years (Range)

69 (19-78)

49 (19-69)

71 (53 - 78)

67 (19-78)

Complete Remissions (CR)

8

2

5

7

CR with incomplete recovery (CRi)

1

0

1

1

Total Composite Complete Remission (CRc)

9

2

6

8

Complete Remission (CR) Rate

40%

67%

50%

54%

Complete Remission Composite (CRc) Rate

45%

67%

60%

62%

Partial Remissions (PRs)

2

0

1

1

Overall Response Rate (CRc’s + PRs) or ORR

55%

67%

70%

69%

CRc Relapsed or Death to Date

2

0

2

2

BMT To Date (in CR’s)

2

0

1

1

See Note 1 below

       

 

Notes for Table 1: Data from MB-106 is for Intent To Treat (ITT) subjects and is preliminary and subject to change.

 

 

 

Expected Milestones for Annamycin AML Development Program

 

H1 2024: Complete MB-106 Phase 1B/2 clinical trial.

H1 2024: MB-106 End of Phase 2 Meeting with FDA.

H2 2024: Feedback from the FDA EOP2 Meeting.

H1 2025: Initiate pivotal trial.

H2 2026: Conclude pivotal trial.

2027: Potential NDA submission.

 

Summary of Financial Results for the First Quarter 2024

 

Research and development (R&D) expense was $4.3 million and $5.7 million for the three months ended March 31, 2024 and 2023, respectively. The decrease of $1.4 million is mainly related to the clinical trials activity levels.

 

General and administrative expense was $2.4 million and $2.6 million for the three months ended March 31, 2024 and 2023, respectively. The decrease of $0.2 million is mainly related to a decrease in regulatory and legal fees.

 

As of March 31, 2024, the Company had cash and cash equivalents of $16.8 million and believes that this cash is sufficient to meet its projected operating requirements, which includes the Company’s current Phase 1B/2 clinical programs and preparations for future clinical trials, into the fourth quarter of 2024.

 

Conference Call and Webcast

 

Moleculin management will host its quarterly conference call and webcast for investors, analysts, and other interested parties Monday, May 13, 2024, at 8:30 AM ET.

 

 

 

Interested participants and investors may access the conference call by dialing (877) 407-0832 (domestic) or (201) 689-8433 (international) and referencing the Moleculin Biotech Conference Call. The live audio webcast will be accessible on the Events page of the Investors section of the Moleculin website, moleculin.com, and will be archived for 90 days.

 

About Moleculin Biotech, Inc.

 

Moleculin Biotech, Inc. is a clinical stage pharmaceutical company with a growing pipeline, including Phase 2 clinical programs, for hard-to-treat tumors and viruses. The Company’s lead program, Annamycin is a next-generation anthracycline designed to avoid multidrug resistance mechanisms and to eliminate the cardiotoxicity common with currently prescribed anthracyclines. Annamycin is currently in development for the treatment of relapsed or refractory acute myeloid leukemia (AML) and soft tissue sarcoma (STS) lung metastases. All interim and preliminary data discussed above are subject to change.

 

Additionally, the Company is developing WP1066, an Immune/Transcription Modulator capable of inhibiting p-STAT3 and other oncogenic transcription factors while also stimulating a natural immune response, targeting brain tumors, pancreatic and other cancers, and WP1220, an analog to WP1066, for the topical treatment of cutaneous T-cell lymphoma. Moleculin is also engaged in the development of a portfolio of antimetabolites, including WP1122 for the potential treatment of viruses, as well as cancer indications including brain tumors, pancreatic and other cancers.

 

For more information about the Company, please visit www.moleculin.com and connect on Twitter, LinkedIn and Facebook.

 

Forward-Looking Statements

 

Some of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Forward-looking statements in this press release include, without limitation, the Company's forecasted cash burn rate (including its estimate of cash sufficient to meet its projected operating requirements) and the achievement of the expected milestones set forth above. Although Moleculin believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. Moleculin has attempted to identify forward-looking statements by terminology including ‘believes,’ ‘estimates,’ ‘anticipates,’ ‘expects,’ ‘plans,’ ‘projects,’ ‘intends,’ ‘potential,’ ‘may,’ ‘could,’ ‘might,’ ‘will,’ ‘should,’ ‘approximately’ or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including those discussed under Item 1A. “Risk Factors” in our most recently filed Form 10-K filed with the Securities and Exchange Commission (“SEC”) and updated from time to time in our Form 10-Q filings and in our other public filings with the SEC. Any forward-looking statements contained in this release speak only as of its date. We undertake no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events.

 

 

Investor Contact:

 

JTC Team, LLC

 

Jenene Thomas

(833) 475-8247

MBRX@jtcir.com

 

 

 

Moleculin Biotech, Inc.

               

Unaudited Condensed Consolidated Balance Sheets

               

(in thousands)

 

March 31, 2024

   

December 31, 2023

 

Current assets:

               

Cash and cash equivalents

  $ 16,824     $ 23,550  

Prepaid expenses and other current assets

    2,133       2,723  

Total current assets

    18,957       26,273  

Furniture and equipment, net

    240       272  

Intangible assets

    11,148       11,148  

Operating lease right-of-use asset

    500       524  

Total assets

  $ 30,845     $ 38,217  
                 

Current liabilities:

               

Accounts payable and accrued expenses and other current liabilities

  $ 5,408     $ 6,815  

Total current liabilities

    5,408       6,815  

Operating lease liability - long-term, net of current portion

    450       474  

Warrant liability - long term

    3,400       4,855  

Total liabilities

    9,258       12,144  

Total stockholders' equity

    21,587       26,073  

Total liabilities and stockholders' equity

  $ 30,845     $ 38,217  

 

Unaudited Condensed Consolidated Statements of Operations

               
   

Three Months Ended March 31,

 

(in thousands, except share and per share amounts)

 

2024

   

2023

 

Revenues

  $ -     $ -  

Operating expenses:

               

Research and development

    4,252       5,687  

General and administrative and depreciation and amortization

    2,425       2,667  

Total operating expenses

    6,677       8,354  

Loss from operations

    (6,677 )     (8,354 )

Other income:

               

Gain from change in fair value of warrant liability

    1,455       39  

Other income, net

    11       8  

Interest income, net

    241       392  

Net loss

    (4,970 )     (7,915 )
                 

Net loss per common share - basic and diluted

  $ (2.02 )   $ (4.13 )

Weighted average common shares outstanding - basic and diluted

    2,466,174       1,916,665  

 

 
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Document And Entity Information
May 13, 2024
Document Information [Line Items]  
Entity, Registrant Name MOLECULIN BIOTECH, INC.
Document, Type 8-K/A
Document, Period End Date May 13, 2024
Entity, Incorporation, State or Country Code DE
Entity, File Number 001-37758
Entity, Tax Identification Number 47-4671997
Entity, Address, Address Line One 5300 Memorial Drive
Entity, Address, City or Town Houston
Entity, Address, State or Province TX
Entity, Address, Postal Zip Code 77007
City Area Code 713
Local Phone Number 300-5160
Written Communications false
Soliciting Material false
Pre-commencement Tender Offer false
Pre-commencement Issuer Tender Offer false
Entity, Emerging Growth Company false
Title of 12(b) Security Common Stock, par value $.001 per share
Trading Symbol MBRX
Security Exchange Name NASDAQ
Amendment Description Form 8-K/A date of report 05-13-24
Amendment Flag true
Entity, Central Index Key 0001659617
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