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                          June 12, 2024

       Walter V. Klemp
       Chief Executive Officer
       Moleculin Biotech, Inc.
       5300 Memorial Drive, Suite 950
       Houston, TX 77007

                                                        Re: Moleculin Biotech,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed June 7, 2024
                                                            File No. 333-280064

       Dear Walter V. Klemp:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Chris
Edwards at 202-551-6761 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Cavas S. Pavri