October 5, 2020

VIA EDGAR SUBMISSION

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, NE

Washington, DC 20549

Attention: James Young

Re: Iterum Therapeutics plc

Iterum Therapeutics Bermuda Limited

Iterum Therapeutics International Limited

Iterum Therapeutics US Limited

Iterum Therapeutics US Holding Limited

Registration Statement on Form S-1

File No. 333-248956

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Iterum Therapeutics plc, Iterum Therapeutics Bermuda Limited, Iterum Therapeutics International Limited, Iterum Therapeutics US Limited and Iterum Therapeutics US Holding Limited (collectively, the “Registrants”) hereby request acceleration of the effective date of the Registration Statement on Form S-1 (File No. 333-248956), as amended (the “Registration Statement”), so that it may become effective at 4:30 p.m., Eastern time, on October 6, 2020, or as soon as practicable thereafter.

Very truly yours,
ITERUM THERAPEUTICS PLC
By:	/s/ Corey N. Fishman
	Name: Corey N. Fishman
	Title: Chief Executive Officer
ITERUM THERAPEUTICS BERMUDA LIMITED
By:	/s/ Louise Barrett
	Name: Louise Barrett
	Title: Director
ITERUM THERAPEUTICS INTERNATIONAL LIMITED
By:	/s/ Louise Barrett
	Name: Louise Barrett
	Title: Director
ITERUM THERAPEUTICS US LIMITED
By:	/s/ Corey N. Fishman
	Name: Corey N. Fishman
	Title: Chief Executive Officer
ITERUM THERAPEUTICS US HOLDING LIMITED
By:	/s/ Corey N. Fishman
	Name: Corey N. Fishman
	Title: Chief Executive Officer

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