Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities:
Net loss	$ (25,794)	$ (16,743)
Adjustments to reconcile net income to net cash used in operating activities:
Foreign exchange loss/(gain)	219	(932)
Other non-cash items	82	73
Accretion of redemption premium on debt	90	18
Share-based compensation	4,258	4,290
Depreciation	263	157
Changes in operating assets and liabilities:
Prepaid expenses	(5)	938
Tax incentive receivable	(585)	(2,313)
Other current assets	942	1,362
Accounts payable	1,255	4,327
Accrued expenses	4,762	3,951
Operating lease liabilities	(152)	(165)
Income taxes	754	141
Other current liabilities	301	(886)
Net cash used in operating activities	(13,610)	(5,782)
Cash flows from investing activities:
Purchases of furniture and equipment	16	0
Net cash used in investing activities	(16)	0
Cash flows from financing activities:
Proceeds from issuance of stock	0	56,862
Proceeds from Oxford Term Loan	0	9,996
Payments of withholding taxes from share-based awards	(3,575)	0
Proceeds from exercise of share options	816	1,827
Net cash (used in)/provided by financing activities	(3,123)	68,685
Effect of exchange rate changes on cash and cash equivalents	(141)	685
Net change in cash and cash equivalents	(16,890)	63,588
Cash and cash equivalents at beginning of the period	271,772	227,827
Cash and cash equivalents at end of the period	254,882	291,415
Supplemental Cash Flow Information [Abstract]
Interest paid	933	244
Payment of debt issuance costs	$ (364)	$ 0