Consolidated Statements of Shareholders’ Equity - USD ($) $ in Thousands	Total	At-The-Market Sales Agreement	Public Stock Offering	Ordinary shares	Ordinary shares At-The-Market Sales Agreement	Ordinary shares Public Stock Offering	Additional paid-in capital	Additional paid-in capital At-The-Market Sales Agreement	Additional paid-in capital Public Stock Offering	Ordinary shares held in treasury	Accumulated other comprehensive loss	Accumulated deficit
Beginning balance (in shares) at Dec. 31, 2020				488,304,446
Beginning balance at Dec. 31, 2020	$ 184,854			$ 31,794			$ 366,411			$ (1,700)	$ (4,601)	$ (207,050)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(55,569)											(55,569)
Issuance of ordinary shares, net of issuance costs (in shares)					873,104
Issuance of ordinary shares, net of issuance costs		$ 733			$ 61			$ 672
Restricted share units vested										1,097		(1,097)
Share-based compensation	25,425						25,425
Common shares withheld for taxes on vested stock awards	(6,850)						(6,850)
Equity settled share-based compensation reclassified as cash-settled	$ (588)						(588)
Ending balance (in shares) at Dec. 31, 2021	480,082,966			489,177,550
Ending balance at Dec. 31, 2021	$ 148,005			$ 31,855			385,070			(603)	(4,601)	(263,716)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(68,701)											(68,701)
Issuance of ordinary shares, net of issuance costs (in shares)					80,696	114,080,000
Issuance of ordinary shares, net of issuance costs		$ 67	$ 140,197		$ 5	$ 6,918		$ 62	$ 133,279
Issuance of ordinary shares to treasury (in shares)				28,000,000
Issuance of ordinary shares to treasury	0			$ 1,748						(1,748)
Restricted share units vested										680		(680)
Share options exercised	1,372						1,250			122
Share-based compensation	14,121						14,121
Common shares withheld for taxes on vested stock awards	(4,723)						(4,723)
Equity settled share-based compensation reclassified as cash-settled	$ 128						128
Ending balance (in shares) at Dec. 31, 2022	606,301,054			631,338,246
Ending balance at Dec. 31, 2022	$ 230,466			$ 40,526			$ 529,187			$ (1,549)	$ (4,601)	$ (333,097)